Preparation and properties of N-glycosylated chitosan/polyvinyl alcohol hydrogels for use in wound dressings

被引：8

作者：

Yi, Yu ^{[1
]}

Huang, Ting ^{[1
]}

Xu, Yunxia ^{[1
]}

Mei, Jianfeng ^{[1
]}

Zhang, Yanlu ^{[1
]}

Wang, Xudong ^{[1
]}

Chen, Jianshu ^{[1
]}

Ying, Guoqing ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310014, Peoples R China

来源：

JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS | 2022年 / 20卷

关键词：

N-glycosylated chitosan; hydrogel; wound dressing; polyvinyl alcohol (PVA); sustained release; CHITOSAN-BASED HYDROGELS;

D O I：

10.1177/22808000221101809

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, and wound healing properties. Their application in wound dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed by loading of ofloxacin. A 2:1 volume ratio of chitosan to PVA was found to be optimal based on swelling and water evaporation rates. The slow-drug-release performance of the blended hydrogel was best when the ofloxacin loading was 5.0%. The ofloxacin-loaded hydrogel shows excellent antimicrobial properties in vitro and wound healing ability in an in vivo rabbit full-thickness excision wound model. The chitosan/PVA blended hydrogel has great potential for use in wound dressings and sustained drug release.

引用

页数：8

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