Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs

被引：108

作者：

Nishikawa, Koji ^{[1
,2
]}

Osawa, Yosuke ^{[3
]}

Kimura, Kiminori ^{[1
,2
]}

机构：

[1] Tokyo Metropolitan Canc, Dept Hepatol, Bunkyo Ku, 3-18-22 Honkomagome, Tokyo 1138677, Japan

[2] Komagome Hosp, Ctr Infect Dis, Bunkyo Ku, 3-18-22 Honkomagome, Tokyo 1138677, Japan

[3] Natl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol, 1-7-1 Kohnodai, Ichikawa, Chiba 2728516, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 10期

关键词：

liver fibrosis; Wnt; -catenin; PRI-724; BETA-CATENIN; TISSUE-REPAIR; STEM-CELLS; WNT; FIBROSIS; INJURY; ROLES; INHIBITION; EXPRESSION; DISEASE;

D O I：

10.3390/ijms19103103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cirrhosis is a form of liver fibrosis resulting from chronic hepatitis and caused by various liver diseases, including viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis, and autoimmune liver disease. Cirrhosis leads to various complications, resulting in poor prognoses; therefore, it is important to develop novel antifibrotic therapies to counter liver cirrhosis. Wnt/-catenin signaling is associated with the development of tissue fibrosis, making it a major therapeutic target for treating liver fibrosis. In this review, we present recent insights into the correlation between Wnt/-catenin signaling and liver fibrosis and discuss the antifibrotic effects of the cAMP-response element binding protein/-catenin inhibitor PRI-724.

引用

页数：12

共 66 条

[1] Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12 [J].