Recent advances in electrochemiluminescence immunoassay based on multiple-signal strategy

被引：90
作者：
Du, Fangxin [1 ,2 ]
Chen, Yequan [1 ]
Meng, Chengda [1 ,2 ]
Lou, Baohua [1 ,2 ]
Zhang, Wei [1 ,2 ]
Xu, Guobao [1 ,2 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
CURRENT OPINION IN ELECTROCHEMISTRY | 2021年 / 28卷
基金：
中国国家自然科学基金;
关键词：
Electrochemiluminescence (ECL); Immunoassay; Multiple-signals; Ratiometric ECL; Multiplex immunoassay; ECL imaging; ELECTROGENERATED CHEMILUMINESCENCE; RESOLVED ELECTROCHEMILUMINESCENCE; BIPOLAR ELECTRODE; BIOSENSOR; RATIOMETRY;
D O I：
10.1016/j.coelec.2021.100725
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Electrochemiluminescence (ECL) has been widely applied in immunoassays because of low background, high sensitivity, and excellent spatiotemporal controllability. In order to meet the increasing demand for high efficiency and accuracy of immunoassays in complex conditions, considerable efforts have been devoted to ECL strategies with multiple-signal outputs. In this short review, we summarize the recent advances of ECL strategies based on multiple-signal outputs, which includes ratiometric ECL, ECL multiplex immunoassay (MIA), and ECL imaging. Their signal generation strategies and analysis applications for immunoassay are discussed in detail. Moreover, the challenges and prospects in this field from us are addressed.
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页数：9
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