Breast cancer;
Colorectal cancer;
Meta-analysis;
Ultraviolet-B;
Vitamin D;
25-Hydroxyvitamin D;
VITAMIN-D STATUS;
SOLAR ULTRAVIOLET-B;
PROSTATE-CANCER;
PANCREATIC-CANCER;
D METABOLITES;
COLON-CANCER;
D REDUCE;
PLASMA;
25-HYDROXYVITAMIN-D;
MORTALITY RATES;
D INSUFFICIENCY;
D O I:
10.1016/j.jphotobiol.2010.04.008
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The evidence is increasing that higher serum 25-hydroxyvitamin D [25(OH)D] levels reduce the risk of many types of cancer. Ecological and observational studies yield the strongest evidence, with support from studies of mechanisms. A key question is identifying the relation between serum 25(OH)D level and cancer incidence. Meta-analyses of such studies is a reasonable approach to determine the serum 25(OH)D level-cancer incidence relation. This paper reports new meta-analyses for breast and colorectal cancers. Currently, the journal literature offers seven prospective breast cancer and ten prospective colorectal cancer studies that can be used. The data for these studies graphed and compared. Data from some of the studies were multiplied by factors to bring all the studies into reasonable agreement with a tentative dose-response relation. The data were fit with a variety of functions; the best fits were nonlinear functions that tended to asymptotically reach a lower odds ratio at higher serum 25(OH)D levels. These analyses estimated that the 50% reduction in incidence occurs for a value of 78 nmol/L compared with the value at 24 nmol/L for breast cancer, and a value of 60 nmol/L compared with the value at 15 nmol/L for colorectal cancer. Although these results are reasonable, some concern exists that a single serum 25(OH)D level, measured years prior to diagnosis of cancer, does not adequately represent the serum levels for the entire period before diagnosis. Future prospective studies should include more serum 25(OH)D level measurements during the study course. (C) 2010 Elsevier B.V. All rights reserved.
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA
NYU, Inst Canc, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Arslan, Alan A.
;
Clendenen, Tess V.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Clendenen, Tess V.
;
Koenig, Karen L.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Koenig, Karen L.
;
Hultdin, Johan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Med Biosci, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Hultdin, Johan
;
Enquist, Kerstin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Enquist, Kerstin
;
Agren, Asa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Agren, Asa
;
Lukanova, Annekatrin
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, GermanyNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Lukanova, Annekatrin
;
Sjodin, Hubert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Med Biosci, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Sjodin, Hubert
;
Zeleniuch-Jacquotte, Anne
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Inst Canc, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Zeleniuch-Jacquotte, Anne
;
Shore, Roy E.
论文数: 0引用数: 0
h-index: 0
机构:
Radiat Effects Res Fdn, Hiroshima 7320815, JapanNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Shore, Roy E.
;
Hallmans, Goran
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Hallmans, Goran
;
Toniolo, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA
NYU, Inst Canc, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Toniolo, Paolo
;
Lundin, Eva
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Med Biosci, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA
NYU, Inst Canc, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Arslan, Alan A.
;
Clendenen, Tess V.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Clendenen, Tess V.
;
Koenig, Karen L.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Koenig, Karen L.
;
Hultdin, Johan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Med Biosci, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Hultdin, Johan
;
Enquist, Kerstin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Enquist, Kerstin
;
Agren, Asa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Agren, Asa
;
Lukanova, Annekatrin
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, GermanyNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Lukanova, Annekatrin
;
Sjodin, Hubert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Med Biosci, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Sjodin, Hubert
;
Zeleniuch-Jacquotte, Anne
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Inst Canc, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Zeleniuch-Jacquotte, Anne
;
Shore, Roy E.
论文数: 0引用数: 0
h-index: 0
机构:
Radiat Effects Res Fdn, Hiroshima 7320815, JapanNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Shore, Roy E.
;
Hallmans, Goran
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Hallmans, Goran
;
Toniolo, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA
NYU, Inst Canc, New York, NY 10016 USANYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA
Toniolo, Paolo
;
Lundin, Eva
论文数: 0引用数: 0
h-index: 0
机构:
Univ Umea, Dept Med Biosci, S-90187 Umea, SwedenNYU, Dept Environm Med, Sch Med, 550 First Ave, New York, NY 10016 USA