Extramedullary T lymphoid blast crisis representing an additional translocation, t(6;8)(q25;q22) in a patient with Philadelphia-positive chronic myelogenous leukemia after allogeneic bone marrow transplantation

被引：6
作者：
Okazuka, K
Toba, K
Kawai, K
Nikkuni, K
Tsuchiyama, J
Momoi, A
Kanazawa, N
Nagai, K
Suzuki, N
Aizawa, Y
机构：
[1] Niigata Univ, Sch Med, Dept Internal Med 1, Niigata 9518520, Japan
[2] Niigata Univ, Sch Med, Dept Dermatol, Niigata 9518520, Japan
[3] Niigata Prefectural Cent Hosp, Dept Internal Med, Joetsu City, Japan
来源：
LEUKEMIA RESEARCH | 2001年 / 25卷 / 12期
关键词：
chronic myelogenous leukemia; T-Lymphoblastic crisis; extramedullary crisis; chromosome translocation; bone marrow transplantation;
D O I：
10.1016/S0145-2126(01)00078-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A patient with extramedullary crisis from chronic myelogenous leukemia after allogeneic bone marrow transplantation is reported. A pathological neck lymph node observed after transplantation revealed pre-T lymphoblastic phenotype, and the fluorescence in situ hybridization (FISH) analysis showed recipient type sex chromosomes and bcr/abl fusion gene. The cells represented an additional translocation, t(6;8)(q25;q22). No rearrangements of the T-cell receptor (TCR) beta, gamma or delta chain genes were observed. The absence of TCR rearrangement indicated the clonogenic. involvement of pluripotent hematopoietic stem cells by Philadelphia chromosome. Bone marrow specimens at that time showed donor type sex chromosomes and no bcr/abl-positive cells by FISH. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1089 / 1094
页数：6
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