The cancer COMPASS: navigating the functions of MLL complexes in cancer

被引：111
作者：
Ford, David J. [1 ]
Dingwall, Andrew K. [1 ,2 ,3 ]
机构：
[1] Loyola Univ Chicago, Stritch Sch Med, Mol Biol & Biochem Grad Program, Maywood, IL 60153 USA
[2] Loyola Univ Chicago, Stritch Sch Med, Oncol Res Inst, Maywood, IL USA
[3] Loyola Univ Chicago, Stritch Sch Med, Dept Pathol, Maywood, IL USA
来源：
CANCER GENETICS | 2015年 / 208卷 / 05期
基金：
美国国家科学基金会;
关键词：
Epigenetics; enhancers; chromatin; lysine methyltransferase; COMPASS complex; B-VIRUS DNA; MUTATIONAL LANDSCAPE; HISTONE METHYLTRANSFERASE; SOMATIC MUTATIONS; BREAST-CANCER; WHOLE-GENOME; GENE-EXPRESSION; COACTIVATOR COMPLEX; RECURRENT MUTATIONS; FREQUENT MUTATIONS;
D O I：
10.1016/j.cancergen.2015.01.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The mixed-lineage leukemia family of histone methyltransferases (MLL1-4, or KMT2A-D) were previously linked to cancer through the founding member, MLL1/KMT2A, which is often involved in translocation-associated gene fusion events in childhood leukemias. However, in recent years, a multitude of tumor exome sequencing studies have revealed that orthologues MLL3/KMT2C and MLL2/KMT2D are mutated in a significant percentage of a large variety of malignancies, particularly solid tumors. These unexpected findings necessitate a deeper inspection into the activities and functional differences between the MLL/KMT2 family members. This review provides an overview of this protein family and its relation to cancers, focusing on the recent links between MLL3/KMT2C and MLL2/4/KMT2D and their potential roles as tumor suppressors in an assortment of cell types.
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收藏
页码：178 / 191
页数：14
相关论文
共 177 条
  • [51] The mutational landscape of chromatin regulatory factors across 4,623 tumor samples
    Gonzalez-Perez, Abel
    Jene-Sanz, Alba
    Lopez-Bigas, Nuria
    [J]. GENOME BIOLOGY, 2013, 14 (09):
  • [52] Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins
    Goo, YH
    Sohn, YC
    Kim, DH
    Kim, SW
    Kang, MJ
    Jung, DJ
    Kwak, E
    Barlev, NA
    Berger, SL
    Chow, VT
    Roeder, RG
    Azorsa, DO
    Meltzer, PS
    Suh, PG
    Song, EJ
    Lee, KJ
    Lee, YC
    Lee, JW
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (01) : 140 - 149
  • [53] The mutational landscape of lethal castration-resistant prostate cancer
    Grasso, Catherine S.
    Wu, Yi-Mi
    Robinson, Dan R.
    Cao, Xuhong
    Dhanasekaran, Saravana M.
    Khan, Amjad P.
    Quist, Michael J.
    Jing, Xiaojun
    Lonigro, Robert J.
    Brenner, J. Chad
    Asangani, Irfan A.
    Ateeq, Bushra
    Chun, Sang Y.
    Siddiqui, Javed
    Sam, Lee
    Anstett, Matt
    Mehra, Rohit
    Prensner, John R.
    Palanisamy, Nallasivam
    Ryslik, Gregory A.
    Vandin, Fabio
    Raphael, Benjamin J.
    Kunju, Lakshmi P.
    Rhodes, Daniel R.
    Pienta, Kenneth J.
    Chinnaiyan, Arul M.
    Tomlins, Scott A.
    [J]. NATURE, 2012, 487 (7406) : 239 - 243
  • [54] Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma
    Green, Michael R.
    Gentles, Andrew J.
    Nair, Ramesh V.
    Irish, Jonathan M.
    Kihira, Shingo
    Liu, Chih Long
    Kela, Itai
    Hopmans, Erik S.
    Myklebust, June H.
    Ji, Hanlee
    Plevritis, Sylvia K.
    Levy, Ronald
    Alizadeh, Ash A.
    [J]. BLOOD, 2013, 121 (09) : 1604 - 1611
  • [55] Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    Gui, Yaoting
    Guo, Guangwu
    Huang, Yi
    Hu, Xueda
    Tang, Aifa
    Gao, Shengjie
    Wu, Renhua
    Chen, Chao
    Li, Xianxin
    Zhou, Liang
    He, Minghui
    Li, Zesong
    Sun, Xiaojuan
    Jia, Wenlong
    Chen, Jinnong
    Yang, Shangming
    Zhou, Fangjian
    Zhao, Xiaokun
    Wan, Shengqing
    Ye, Rui
    Liang, Chaozhao
    Liu, Zhisheng
    Huang, Peide
    Liu, Chunxiao
    Jiang, Hui
    Wang, Yong
    Zheng, Hancheng
    Sun, Liang
    Liu, Xingwang
    Jiang, Zhimao
    Feng, Dafei
    Chen, Jing
    Wu, Song
    Zou, Jing
    Zhang, Zhongfu
    Yang, Ruilin
    Zhao, Jun
    Xu, Congjie
    Yin, Weihua
    Guan, Zhichen
    Ye, Jiongxian
    Zhang, Hong
    Li, Jingxiang
    Kristiansen, Karsten
    Nickerson, Michael L.
    Theodorescu, Dan
    Li, Yingrui
    Zhang, Xiuqing
    Li, Songgang
    Wang, Jian
    [J]. NATURE GENETICS, 2011, 43 (09) : 875 - 878
  • [56] KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation
    Guo, Changcun
    Chen, Lee H.
    Huang, Yafen
    Chang, Chun-Chi
    Wang, Ping
    Pirozzi, Christopher J.
    Qin, Xiaoxia
    Bao, Xuhui
    Greer, Paula K.
    McLendon, Roger E.
    Yan, Hai
    Keir, Stephen T.
    Bigner, Darell D.
    He, Yiping
    [J]. ONCOTARGET, 2013, 4 (11) : 2144 - 2153
  • [57] Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways
    Guo, Changcun
    Chang, Chun-Chi
    Wortham, Matthew
    Chen, Lee H.
    Kernagis, Dawn N.
    Qin, Xiaoxia
    Cho, Young-Wook
    Chi, Jen-Tsan
    Grant, Gerald A.
    McLendon, Roger E.
    Yan, Hai
    Ge, Kai
    Papadopoulos, Nickolas
    Bigner, Darell D.
    He, Yiping
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (43) : 17603 - 17608
  • [58] Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
    Guo, Guangwu
    Sun, Xiaojuan
    Chen, Chao
    Wu, Song
    Huang, Peide
    Li, Zesong
    Dean, Michael
    Huang, Yi
    Jia, Wenlong
    Zhou, Quan
    Tang, Aifa
    Yang, Zuoquan
    Li, Xianxin
    Song, Pengfei
    Zhao, Xiaokun
    Ye, Rui
    Zhang, Shiqiang
    Lin, Zhao
    Qi, Mingfu
    Wan, Shengqing
    Xie, Liangfu
    Fan, Fan
    Nickerson, Michael L.
    Zou, Xiangjun
    Hu, Xueda
    Xing, Li
    Lv, Zhaojie
    Mei, Hongbin
    Gao, Shengjie
    Liang, Chaozhao
    Gao, Zhibo
    Lu, Jingxiao
    Yu, Yuan
    Liu, Chunxiao
    Li, Lin
    Fang, Xiaodong
    Jiang, Zhimao
    Yang, Jie
    Li, Cailing
    Zhao, Xin
    Chen, Jing
    Zhang, Fang
    Lai, Yongqi
    Lin, Zheguang
    Zhou, Fangjian
    Chen, Hao
    Chan, Hsiao Chang
    Tsang, Shirley
    Theodorescu, Dan
    Li, Yingrui
    [J]. NATURE GENETICS, 2013, 45 (12) : 1459 - U213
  • [59] Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
    Guo, Guangwu
    Gui, Yaoting
    Gao, Shengjie
    Tang, Aifa
    Hu, Xueda
    Huang, Yi
    Jia, Wenlong
    Li, Zesong
    He, Minghui
    Sun, Liang
    Song, Pengfei
    Sun, Xiaojuan
    Zhao, Xiaokun
    Yang, Sangming
    Liang, Chaozhao
    Wan, Shengqing
    Zhou, Fangjian
    Chen, Chao
    Zhu, Jialou
    Li, Xianxin
    Jian, Minghan
    Zhou, Liang
    Ye, Rui
    Huang, Peide
    Chen, Jing
    Jiang, Tao
    Liu, Xiao
    Wang, Yong
    Zou, Jing
    Jiang, Zhimao
    Wu, Renhua
    Wu, Song
    Fan, Fan
    Zhang, Zhongfu
    Liu, Lin
    Yang, Ruilin
    Liu, Xingwang
    Wu, Haibo
    Yin, Weihua
    Zhao, Xia
    Liu, Yuchen
    Peng, Huanhuan
    Jiang, Binghua
    Feng, Qingxin
    Li, Cailing
    Xie, Jun
    Lu, Jingxiao
    Kristiansen, Karsten
    Li, Yingrui
    Zhang, Xiuqing
    [J]. NATURE GENETICS, 2012, 44 (01) : 17 - 19
  • [60] Comprehensive genomic characterization of squamous cell lung cancers
    Hammerman, Peter S.
    Lawrence, Michael S.
    Voet, Douglas
    Jing, Rui
    Cibulskis, Kristian
    Sivachenko, Andrey
    Stojanov, Petar
    McKenna, Aaron
    Lander, Eric S.
    Gabriel, Stacey
    Getz, Gad
    Sougnez, Carrie
    Imielinski, Marcin
    Helman, Elena
    Hernandez, Bryan
    Pho, Nam H.
    Meyerson, Matthew
    Chu, Andy
    Chun, Hye-Jung E.
    Mungall, Andrew J.
    Pleasance, Erin
    Robertson, A. Gordon
    Sipahimalani, Payal
    Stoll, Dominik
    Balasundaram, Miruna
    Birol, Inanc
    Butterfield, Yaron S. N.
    Chuah, Eric
    Coope, Robin J. N.
    Corbett, Richard
    Dhalla, Noreen
    Guin, Ranabir
    Hirst, Anhe Carrie
    Hirst, Martin
    Holt, Robert A.
    Lee, Darlene
    Li, Haiyan I.
    Mayo, Michael
    Moore, Richard A.
    Mungall, Karen
    Nip, Ka Ming
    Olshen, Adam
    Schein, Jacqueline E.
    Slobodan, Jared R.
    Tam, Angela
    Thiessen, Nina
    Varhol, Richard
    Zeng, Thomas
    Zhao, Yongjun
    Jones, Steven J. M.
    [J]. NATURE, 2012, 489 (7417) : 519 - 525
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