Neurohumoral Stimulation

被引：87

作者：

Zucker, Irving H. ^{[1
]}

Patel, Kaushik P. ^{[1
]}

Schultz, Harold D. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE 68198 USA

来源：

HEART FAILURE CLINICS | 2012年 / 8卷 / 01期

关键词：

Chronic heart failure; Neurohumoral activation; Baroreflex; Sympathoexcitation; Carotid body chemoreflex; CONGESTIVE-HEART-FAILURE; SYMPATHETIC AFFERENT REFLEX; EXERCISE PRESSOR REFLEX; NITRIC-OXIDE SYNTHASE; CAROTID-SINUS BARORECEPTORS; BODY NEGATIVE-PRESSURE; RECEPTOR UP-REGULATION; ACUTE VOLUME EXPANSION; RENAL NERVE DISCHARGE; CENTRAL ANG-II;

D O I：

10.1016/j.hfc.2011.08.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.

引用

页码：87 / +

页数：15

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