Deep Brain Stimulation in Huntington's DiseasePreliminary Evidence on Pathophysiology, Efficacy and Safety

被引：37

作者：

Wojtecki, Lars ^{[1
,2
]}

Groiss, Stefan Jun ^{[1
,2
]}

Hartmann, Christian Johannes ^{[1
,2
]}

Elben, Saskia ^{[1
,2
]}

Omlor, Sonja ^{[2
]}

Schnitzler, Alfons ^{[1
,2
]}

Vesper, Jan ^{[3
]}

机构：

[1] Univ Dusseldorf, Fac Med, Dept Neurol, Moorenstr 5, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Fac Med, Inst Clin Neurosci & Med Psychol, Moorenstr 5, D-40225 Dusseldorf, Germany

[3] Univ Dusseldorf, Fac Med, Dept Funct Neurosurg & Stereotaxy, Moorenstr 5, D-40225 Dusseldorf, Germany

来源：

BRAIN SCIENCES | 2016年 / 6卷 / 03期

关键词：

chorea; Huntington; deep brain stimulation; DBS; safety pathophysiology; recordings; globus pallidus; GLOBUS-PALLIDUS STIMULATION; TERM-FOLLOW-UP; PARKINSONS-DISEASE; BASAL GANGLIA; PROJECTION NEURONS; FUNCTIONAL-ANATOMY; RAT MODEL; GPI-DBS; DYSTONIA; MOTOR;

D O I：

10.3390/brainsci6030038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Huntington's disease (HD) is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS) of the pallidum is a promising symptomatic treatment targeting the core motor symptom: chorea. This article gives an overview of preliminary evidence on pathophysiology, safety and efficacy of DBS in HD.

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页数：15

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