Prostaglandins may participate in opioidergic and cholinergic control of the diurnal changes of tuberoinfundibular dopaminergic neuronal activity and serum prolactin level in ovariectomized, estrogen-treated rats

被引:6
作者
Chu, YC
Tsou, MY
Pan, JT [1 ]
机构
[1] Natl Yang Ming Univ, Dept Physiol, Sch Life Sci & Med, Taipei 11211, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Dept Clin Med, Taipei 11211, Taiwan
[3] Vet Gen Hosp, Dept Anesthesiol, Taipei, Taiwan
关键词
prostaglandins; circadian rhythm; prolactin; tuberoinfundibular dopaminergic neuron; nicotine; fentanyl; ketanserin;
D O I
10.1016/S0361-9230(01)00605-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The roles of prostaglandins (PGs) involved in opioidergic, cholinergic, and serotonergic regulation of the diurnal changes of tuberoinfundibular dopaminergic (TIDA) neuronal activities were investigated in ovariectomized, estrogen-treated rats, Treatment with naloxone [10 mg/kg, intraperitoneal (i.p.)], atropine (5 mg/kg, i.p.), or ketanserin (10 mg/kg, i.p.) at either 1200 or 1400 h prevented the afternoon decrease of TIDA neuronal activity and the prolactin (PRL) surge. Intracerebroventricular (i.c.v.) injection of PGE(1) (5 mug/3 mul/rat) at 1500 h significantly reversed the effects of naloxone and atropine, but not that of ketanserin. In ovariectomized, estrogen-primed rats pretreated with indomethacin, i.c.v. injection of either nicotine (10 ng/rat) or fentanyl (10 ng/rat) failed to suppress the TIDA neuronal activity and to stimulate the PRL secretion. These data suggest that PG may be involved in opioidergic and cholinergic control of the diurnal changes of TIDA neuronal activity and the PRL secretion in ovariectomized (OVX) + E-2 rats. (C) 2001 Elsevier Science Inc.
引用
收藏
页码:61 / 65
页数:5
相关论文
共 29 条
  • [1] BHATTACHARYA SK, 1989, INDIAN J EXP BIOL, V27, P393
  • [2] DISTRIBUTION AND CHARACTERIZATION OF CYCLOOXYGENASE IMMUNOREACTIVITY IN THE OVINE BRAIN
    BREDER, CD
    SMITH, WL
    RAZ, A
    MASFERRER, J
    SEIBERT, K
    NEEDLEMAN, P
    SAPER, CB
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 322 (03) : 409 - 438
  • [3] ACETYLCHOLINE DRAMATICALLY INCREASES PROSTANOID SYNTHESIS IN PIGLET PARIETAL CORTEX
    BUSIJA, DW
    WAGERLE, LC
    POURCYROUS, M
    LEFFLER, CW
    [J]. BRAIN RESEARCH, 1988, 439 (1-2) : 122 - 126
  • [4] CHU YC, IN PRESS BRAIN RES B
  • [5] APOMORPHINE AND MORPHINE STIMULATE PROSTAGLANDIN BIOSYNTHESIS
    COLLIER, HOJ
    MCDONALD.WJ
    SAEED, SA
    [J]. NATURE, 1974, 252 (5478) : 56 - 58
  • [6] COLLIER HOJ, 1974, BRIT J PHARMACOL, V52, pP116
  • [7] EVERETT JW, 1989, NEUROBIOLOGY REPROD
  • [8] CENTRAL AND PERIPHERAL SITES OF ACTION FOR THE PROTECTIVE EFFECT OF OPIOIDS OF THE RAT STOMACH
    FERRI, S
    ARRIGOREINA, R
    CANDELETTI, S
    COSTA, G
    MURARI, G
    SPERONI, E
    SCOTO, G
    [J]. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1983, 15 (04): : 409 - 418
  • [9] PARTIAL CHARACTERIZATION OF A NEUROTRANSMITTER PATHWAY REGULATING THE INVIVO RELEASE OF PROLACTIN
    FLORES, CM
    HULIHANGIBLIN, BA
    HORNBY, PJ
    LUMPKIN, MD
    KELLAR, KJ
    [J]. NEUROENDOCRINOLOGY, 1992, 55 (05) : 519 - 528
  • [10] QUANTITATIVE-ANALYSIS OF PHYSIOLOGICAL-ROLE OF ESTRADIOL AND PROGESTERONE IN CONTROL OF TONIC AND SURGE SECRETION OF LUTEINIZING-HORMONE IN RAT
    GOODMAN, RL
    [J]. ENDOCRINOLOGY, 1978, 102 (01) : 142 - 150