The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems

被引：319

作者：

Zhu, Ying ^{[1
]}

Li, Jing ^{[1
]}

Li, Wenxin ^{[1
]}

Zhang, Yu ^{[1
]}

Yang, Xiafeng ^{[1
,2
]}

Chen, Nan ^{[1
]}

Sun, Yanhong ^{[1
]}

Zhao, Yun ^{[2
]}

Fan, Chunhai ^{[1
]}

Huang, Qing ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Phys Biol Lab, Shanghai 201800, Peoples R China

[2] Sichuan Univ, Sch Life Sci, Chengdu 610064, Sichuan, Peoples R China

来源：

THERANOSTICS | 2012年 / 2卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Nanodiamonds (NDs); biocompatibility; drug delivery system; adsorption model; versatility; WALLED CARBON NANOTUBES; FLUORESCENT NANODIAMONDS; IN-VIVO; BIODISTRIBUTION; TOXICITY; CYTOTOXICITY; GRAPHENE; PERSPECTIVES; PARTICLES; CHEMISTRY;

D O I：

10.7150/thno.3627

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and more attention in biomedicine recently due to their excellent physical and chemical properties. This paper summarizes the main results from the in vitro and in vivo safety assessments of NDs and reports the application of NDs in the development of drug delivery systems. In view of the NDs' characteristics of easy formation of a porous cluster structure in solution, an adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging.

引用

页码：302 / 312

页数：11

共 65 条

[21] Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes [J].

Jia, Nengqin ;

Lian, Qiong ;

Shen, Hebei ;

Wang, Chen ;

Li, Xingyu ;

Yang, Zhongnan .

NANO LETTERS, 2007, 7 (10) :2976-2980

[22] Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation [J].

Lam, CW ;

James, JT ;

McCluskey, R ;

Hunter, RL .

TOXICOLOGICAL SCIENCES, 2004, 77 (01) :126-134

[23] Nanodiamond-Embedded Microfilm Devices for Localized Chemotherapeutic Elution [J].

Lam, Robert ;

Chen, Mark ;

Pierstorff, Erik ;

Huang, Houjin ;

Osawa, Eiji ;

Ho, Dean .

ACS NANO, 2008, 2 (10) :2095-2102

[24] Nanodiamonds as intracellular transporters of chemotherapeutic drug [J].

Li, Jing ;

Zhu, Ying ;

Li, Wenxin ;

Zhang, Xiaoyong ;

Peng, Yan ;

Huang, Qing .

BIOMATERIALS, 2010, 31 (32) :8410-8418

[25] Preparation of 99mTc-C60(OH)x and its biodistribution studies [J].

Li, QN ;

Xiu, Y ;

Zhang, XD ;

Liu, RL ;

Du, QQ ;

Shun, XG ;

Chen, SL ;

Li, WX .

NUCLEAR MEDICINE AND BIOLOGY, 2002, 29 (06) :707-710

[26] TAT-conjugated nanodiamond for the enhanced delivery of doxorubicin [J].

Li, Xixuan ;

Shao, Jianqun ;

Qin, Ying ;

Shao, Chen ;

Zheng, Tingting ;

Ye, Ling .

JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (22) :7966-7973

[27]

Li YG, 2001, J RADIOANAL NUCL CH, V250, P363

[28] Biocompatible and detectable carboxylated nanodiamond on human cell [J].

Liu, Kuang-Kai ;

Cheng, Chia-Liang ;

Chang, Chia-Ching ;

Chao, Jui-I .

NANOTECHNOLOGY, 2007, 18 (32)

[29] Covalent linkage of nanodiamond-paclitaxel for drug delivery and cancer therapy [J].

Liu, Kuang-Kai ;

Zheng, Wen-Wei ;

Wang, Chi-Ching ;

Chiu, Yu-Chung ;

Cheng, Chia-Liang ;

Lo, Yu-Shiu ;

Chen, Chinpiao ;

Chao, Jui-I .

NANOTECHNOLOGY, 2010, 21 (31)

[30] Endocytic carboxylated nanodiamond for the labeling and tracking of cell division and differentiation in cancer and stem cells [J].

Liu, Kuang-Kai ;

Wang, Chi-Ching ;

Cheng, Chia-Liang ;

Chao, Jui-I .

BIOMATERIALS, 2009, 30 (26) :4249-4259

← 1 2 3 4 5 6 7 →