Ethylene glycol poisoning: Quintessential clinical toxicology; analytical conundrum

被引：47
作者：
Porter, William H. [1 ]
机构：
[1] Univ Kentucky, Med Ctr, Dept Pathol & Lab Med, Lexington, KY 40536 USA
来源：
CLINICA CHIMICA ACTA | 2012年 / 413卷 / 3-4期
关键词：
Ethylene glycol; Glycolic acid; Oxalic acid; Gas chromatography; Mass spectrometry; Enzymatic assays; LIQUID-CHROMATOGRAPHIC DETERMINATION; MASS-SPECTROMETRIC IDENTIFICATION; FALSELY ELEVATED LACTATE; INDUCED LACTIC-ACIDOSIS; PROPYLENE-GLYCOL; DIETHYLENE GLYCOL; CALCIUM-OXALATE; ENZYMATIC ASSAY; OSMOLAL GAP; BIOLOGICAL SPECIMENS;
D O I：
10.1016/j.cca.2011.10.034
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Ethylene glycol poisoning is a medical emergency that presents challenges both for clinicians and clinical laboratories. Untreated, it may cause morbidly or death, but effective therapy is available, if administered timely. However, the diagnosis of ethylene glycol poisoning is not always straightforward. Thus, measurement of serum ethylene glycol, and ideally glycolic acid, its major toxic metabolite in serum, is definitive. Yet measurement of these structurally rather simple compounds is but simple. This review encompasses an assessment of analytical methods for the analytes relevant for the diagnosis and prognosis of ethylene glycol poisoning and of the role of the ethylene glycol metabolites, glycolic and oxalic acids, in its toxicity. (C) 2011 Elsevier B.V. All rights reserved.
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收藏
页码：365 / 377
页数：13
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