State-of-the-Art Technology of Model Organisms for Current Human Medicine

被引：11

作者：

Konno, Masamitsu ^{[1
]}

Asai, Ayumu ^{[1
,2
,3
]}

Kitagawa, Toru ^{[1
,3
,4
]}

Yabumoto, Masami ^{[1
,3
,5
]}

Ofusa, Ken ^{[1
,6
]}

Arai, Takahiro ^{[1
,7
]}

Hirotsu, Takaaki ^{[1
,8
]}

Doki, Yuichiro ^{[1
,3
]}

Eguchi, Hidetoshi ^{[1
,3
]}

Ishii, Hideshi ^{[1
,3
]}

机构：

[1] Osaka Univ, Ctr Med Innovat & Translat Res, Grad Sch Med, Yamadaoka 2-2, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Artificial Intelligence Res Ctr, Inst Sci & Ind Res, 8-1 Mihogaoka, Ibaraki, Osaka 5670047, Japan

[3] Osaka Univ, Grad Sch Med, Dept Gastroenterol Surg, Suita, Osaka 5650871, Japan

[4] Kyowa Kai Med Corp, Kobe, Hyogo 6660015, Japan

[5] Kinshu Kai Med Corp, Osaka 5580041, Japan

[6] Idea Consultants Inc, Food & Life Sci Lab, Prophoenix Div, Osaka, Osaka 5598519, Japan

[7] Unitech Co Ltd, Kashiwa, Chiba 2770005, Japan

[8] Hirotsu Bio Sci Inc, Tokyo 1070062, Japan

来源：

DIAGNOSTICS | 2020年 / 10卷 / 06期

关键词：

biology; diagnosis; therapy; regenerative medicine; FLUORESCENT-PROBES; ZEBRAFISH; GENOME; CELLS; GENERATION; PANCREAS;

D O I：

10.3390/diagnostics10060392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the 1980s, molecular biology has been used to investigate medical field mechanisms that still require the use of crude biological materials in order to achieve their necessary goals. Transcription factor-induced pluripotent stem cells are used in regenerative medicine to screen drugs and to support lost tissues. However, these cells insufficiently reconstruct whole organs and require various intact cells, such as damaged livers and diabetic pancreases. For efficient gene transfer in medical use, virally mediated gene transfers are used, although immunogenic issues are investigated. To obtain efficient detective and diagnostic power in intractable diseases, biological tools such as roundworms and zebrafish have been found to be useful for high-throughput screening (HST) and diagnosis. Taken together, this biological approach will help to fill the gaps between medical needs and novel innovations in the field of medicine.

引用

页数：11

共 72 条

[1] An elegant mind: Learning and memory in Caenorhabditis elegans [J].