Chalcones-Sulphonamide Hybrids: Synthesis, Characterization and Anticancer Evaluation

被引：5

作者：

Khanusiya, Mahammadali ^{[1
]}

Gadhawala, Zakirhusen ^{[1
]}

机构：

[1] HNSB Ltd Sci Coll, Dept Chem, Himatnagar, Gujarat, India

来源：

JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE | 2019年 / 63卷 / 02期

关键词：

Chalcones-sulphonamide hybrid; Anticancer; Cell Lines; Cytotoxicity; DERIVATIVES; ANTIOXIDANT;

D O I：

10.5012/jkcs.2019.63.2.85

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A panel of chalcone-sulphonamide hybrids has been designed by tethering appropriate sulphonamide scaffold with substituted chalcones as a multi-target drug for anticancer screening. Chalcones were prepared by Claisen-Schmidt condensation reaction of a substituted aldehyde with para aminoacetophenone. All the synthesized compounds were evaluated against selected five cancer cell lines, MCF-7 (Breast cancer), DU-145 (Human prostate Carcinoma), HCT-15 (Colon cancer), NCIH-522 (stage 2, adenocarcinoma; non-small cell lung cancer) and HT-3 (Human cervical cancer). Most of the synthesized chalcone-sulphonamide hybrids showed amended cytotoxic activity against various cancer cell lines which may be attributed to the linkage of sulphonamide with chalcone skeleton. The synthesized compounds were characterized by FT-IR, H-1 NMR, C-13 NMR and HR-LCMS and spectral study assert the structures of synthesized sulphonamide-chalcone hybrids.

引用

页码：85 / 93

页数：9

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