Transdermal drug delivery: A comparative analysis of skin impedance models and parameters

被引：9

作者：

Coston, AF ^{[1
]}

Li, JKJ ^{[1
]}

机构：

[1] Ethicon Inc, Instrumentat & Elect, Somerville, NJ 08876 USA

来源：

PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH | 2003年 / 25卷

关键词：

skin impedance; drug delivery systems; iontophoresis;

D O I：

10.1109/IEMBS.2003.1280545

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Variability in skin impedance can significantly influence the effectiveness of transdermal drug delivery. In order to optimize drug delivery, skin impedance frequency response must be considered. Several electrical models for skin impedance and a comparative analysis of different model parameters are presented in an attempt to identify critical parameters for an efficient drug delivery through iontophoresis. It was concluded that skin resistance and capacitance, as well as the mode of stimulation are important considerations in optimal transdermal drug delivery.

引用

页码：2982 / 2985

页数：4