Asymmetric synthesis of (R)-2-chloro-1-(m-chlorophenyl)ethanol using acetone powder of Geotrichum candidum

被引：29

作者：

Hamada, H

Miura, T

Kumobayashi, H

Matsuda, T

Harada, T

Nakamura, K

机构：

[1] Okayama Univ Sci, Dept Appl Sci, Okayama 7000005, Japan

[2] Takasago Int Corp, Hiratsuka, Kanagawa 2540073, Japan

[3] Ryukoku Univ, Fac Sci & Technol, Dept Chem Mat, Shiga 5202194, Japan

[4] Kyoto Univ, Chem Res Inst, Kyoto 6110011, Japan

来源：

BIOTECHNOLOGY LETTERS | 2001年 / 23卷 / 19期

关键词：

biotransformation; chiral alcohols; enantioselective reduction; Geotrichum candidum;

D O I：

10.1023/A:1011922823367

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The asymmetric synthesis of (R)-2-chloro-1-(m-chlorophenyl)ethanol, a precursor for a key intermediate of an important class of drugs, was achieved by reduction of the corresponding ketone using an acetone powder of Geotrichum candidum with 98% ee and 94% yield based on the starting amount of ketone.

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页码：1603 / 1606

页数：4

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