A role for epidermal growth factor receptor in idiopathic pulmonary fibrosis onset

被引：22

作者：

Martinelli, Marcella ^{[1
,2
]}

Pacilli, Angela Maria Grazia ^{[3
]}

Rivetti, Stefano ^{[1
,2
]}

Lauriola, Mattia ^{[1
,2
]}

Fasano, Luca ^{[4
]}

Carbonara, Paolo ^{[3
]}

Mattei, Gabriella ^{[1
,2
]}

Valentini, Ilaria ^{[3
]}

Scapoli, Luca ^{[1
,2
]}

Solmi, Rossella ^{[1
,2
]}

机构：

[1] Univ Bologna, Dipartimento Istol Embriol & Biol Applicata, I-40126 Bologna, Italy

[2] Ctr Ric Genet Mol Fdn CARISBO, Bologna, Italy

[3] Univ Bologna, Dipartimento Med Interna Invecchiamento & Malatti, I-40138 Bologna, Italy

[4] UO Pneumol & TI Resp, Policlin S Orsola Malpighi, Dipartimento Cardio Toraco Vascolare, I-40138 Bologna, Italy

来源：

MOLECULAR BIOLOGY REPORTS | 2011年 / 38卷 / 07期

关键词：

Idiopathic pulmonary fibrosis; EGFR; HER2; HER3; Polymorphisms; FACTOR-ALPHA; MESENCHYMAL TRANSITION; EPITHELIAL-CELLS; LUNG FIBROBLASTS; EGF RECEPTOR; EXPRESSION; MICE; MYOFIBROBLASTS; INHIBITORS; MATRIX;

D O I：

10.1007/s11033-010-0594-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In idiopathic pulmonary fibrosis (IPF) patients the presence of missense polymorphisms (SNP) in members of the epidermal growth factor receptor (EGFR) family or their genetic association could influence the binding affinity of natural ligands, modifying the expression and the behavior of the correlated genes. EGFR family members are particularly involved in the epithelial injury and fibrotic process in IPF. Genetic variations in HER family of receptors may alter the possible therapeutic efficacy of EGFR inhibitors. This study aimed to analyze the relationships between IPF and specific EGF receptor family functional polymorphisms. We tested the presence of common EGFR, HER2 and HER3 non-synonymous SNPs in the peripheral blood of 20 Italian IPF patients and their association with the disease. Our data indicated that the HER2 variant allele frequency was significantly lower in patients than in controls, with an odds ratio of 0.31 (95% CI 0.080, 0.98). Our finding suggests that HER2 variant could be a protective factor against IPF onset.

引用

页码：4613 / 4617

页数：5

共 28 条

[1] Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis [J].