Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010

被引:71
作者
Ikeda, Tatsuya [1 ]
Mizuta, Katsumi [1 ]
Abiko, Chieko [1 ]
Aoki, Yoko [1 ]
Itagaki, Tsutomu [2 ]
Katsushima, Fumio [3 ]
Katsushima, Yuriko [3 ]
Matsuzaki, Yoko [4 ,5 ]
Fuji, Naoko [6 ]
Imamura, Tadatsugu [6 ]
Oshitani, Hitoshi [6 ]
Noda, Masahiro [7 ]
Kimura, Hirokazu [7 ]
Ahiko, Tadayuki [1 ]
机构
[1] Yamagata Prefectural Inst Publ Hlth, Dept Microbiol, Yamagata 9900031, Japan
[2] Yamanobe Pediat Clin, Yamagata, Japan
[3] Katsushima Pediat Clin, Yamagata, Japan
[4] Dept Infect Dis, Yamagata, Japan
[5] Yamagata Univ, Fac Med, Yamagata 990, Japan
[6] Tohoku Univ, Grad Sch Med, Dept Virol, Sendai, Miyagi 9808575, Japan
[7] Natl Inst Infect Dis, Infect Dis Surveillance Ctr, Tokyo 2080011, Japan
基金
日本学术振兴会;
关键词
Acute respiratory infection; enterovirus; 68; reverse transcription polymerase chain reaction; virus isolation; CHILDREN; ILLNESS;
D O I
10.1111/j.1348-0421.2012.00411.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To clarify the epidemiology of enterovirus 68 (EV68), which is one of the most rarely identified enteroviruses, virus isolation and molecular screening using RT-PCR was performed on 6307 respiratory specimens collected at pediatric clinics in Yamagata, Japan between 2005 and 2010. In the years 20052009, 10, 1, 2, 0, and 2 (40) EV68-positive cases, respectively, were identified by RT-PCR. In 2010, 40 cases were identified altogether: 2 by isolation only, 26 by RT-PCR only, and 12 by both isolation and RT-PCR. Phylogenetic analysis indicated that plural genetically distinct clusters co-circulated. These results suggest that that difficulty in EV68 isolation leads to an underestimation of the prevalence of EV68 infections.
引用
收藏
页码:139 / 143
页数:5
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