A Rare Case of Hemophagocytic Lymphohistiocytosis Associated With Myelodysplastic Syndrome and Trisomy 8 in a Pediatric Patient

被引：1

作者：

Kim, Seh Hyun ^{[1
]}

Yi, Dae Yong ^{[1
]}

Lee, Na Mi ^{[1
]}

Yun, Sin Weon ^{[1
]}

Chae, Soo Ahn ^{[1
]}

Lim, In Seok ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Med, Dept Pediat, Seoul, South Korea

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2019年 / 41卷 / 01期

关键词：

hemophagocytic lymphohistiocytosis; myelodysplastic syndrome; chromosome; 8; trisomy; CLINICAL-FEATURES; T-CELLS; SPECTRUM; SUBTYPES; CHILDREN; MDS;

D O I：

10.1097/MPH.0000000000001174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is a rare disease resulting in clinical and biochemical manifestations of extreme inflammation. Myelodysplastic syndrome (MDS) represents a heterogenous group of clonal hematopoietic disorders. The development of MDS is common in children with trisomy of chromosome 8. Here, we report a fatal case of 8-year-old girl who was admitted to the emergency department with status epilepticus, and later diagnosed with HLH associated with MDS and trisomy of chromosome 8. We believe this is the first reported case of HLH associated with MDS and trisomy 8 in a pediatric patient.

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页码：E57 / E59

页数：3

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