Stroke Prevention in Atrial Fibrillation: Current Status and Near-Future Directions

被引：15

作者：

De Caterina, Raffaele ^{[1
,2
]}

Hylek, Elaine M. ^{[3
]}

机构：

[1] Univ G DAnnunzio, Inst Cardiol, Chieti, Italy

[2] Univ G DAnnunzio, Ctr Excellence Aging, Chieti, Italy

[3] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2011年 / 124卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Anticoagulants; Antithrombotic therapy; Atrial fibrillation; Stroke; Thromboembolism; CLOPIDOGREL PLUS ASPIRIN; VITAMIN-K ANTAGONIST; EURO HEART SURVEY; RISK STRATIFICATION; ANTITHROMBOTIC THERAPY; ORAL ANTICOAGULATION; PREDICTING STROKE; ELDERLY-PATIENTS; CLINICAL-TRIALS; WARFARIN;

D O I：

10.1016/j.amjmed.2011.03.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prevention of atrial fibrillation-related stroke is an important part of atrial fibrillation management. However, stroke risk is not homogeneous and varies with associated morbidities and risk factors. Risk stratification schemes have been developed that categorize patients' stroke risk into classes based on a combination of risk factors. According to the calculated level of risk, guidelines recommend patients with atrial fibrillation receive antithrombotic therapy either as a vitamin K antagonist or aspirin. Despite recommendations, however, many patients with atrial fibrillation do not receive adequate thromboprophylaxis. We will discuss some of the underlying reasons, in part related to the drawbacks associated with vitamin K antagonists. These highlight the need for new anticoagulants in atrial fibrillation. The novel oral anticoagulants in development may overcome some of the limitations of vitamin K antagonists and address their underuse and safety concerns. (C) 2011 Elsevier Inc. All rights reserved. The American Journal of Medicine (2011) 124, 793-799

引用

页码：793 / 799

页数：7

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