DC-SIGN and LFA-1: a battle for ligand

被引：59
作者：
Bleijs, DA
Geijtenbeek, TBH
Figdor, CG
van Kooyk, Y
机构：
[1] Free Univ Amsterdam, Med Ctr, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands
[2] Univ Nijmegen, Med Ctr, Dept Tumor Immunol, NL-6500 HB Nijmegen, Netherlands
来源：
TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 08期
关键词：
D O I：
10.1016/S1471-4906(01)01974-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.
引用
收藏
页码：457 / 463
页数：7
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