Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

被引：57

作者：

Wolff, Amy R. ^{[1
]}

Cheyne, Kirsten R. ^{[1
]}

Bilkey, David K. ^{[1
]}

机构：

[1] Univ Otago, Dept Psychol, Dunedin, New Zealand

来源：

BEHAVIOURAL BRAIN RESEARCH | 2011年 / 225卷 / 01期

关键词：

Immune; Context; Memory; Reversal; Schizophrenia; Rat; NEURODEVELOPMENTAL ANIMAL-MODEL; DISRUPTED LATENT INHIBITION; PERIRHINAL CORTEX; HIPPOCAMPAL-FORMATION; OBJECT RECOGNITION; DOPAMINERGIC HYPERFUNCTION; COGNITIVE INFLEXIBILITY; SPATIAL LOCALIZATION; EXCITOTOXIC LESIONS; PRENATAL INFECTION;

D O I：

10.1016/j.bbr.2011.07.033

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：382 / 387

页数：6

共 77 条

[1] EPIDEMIOLOGIC EVIDENCE THAT MATERNAL INFLUENZA CONTRIBUTES TO THE ETIOLOGY OF SCHIZOPHRENIA - AN ANALYSIS OF SCOTTISH, ENGLISH, AND DANISH DATA [J].