SYNTHESIS FROM (+)-α-PINENE OF OPTICALLY ACTIVE MACROCYCLES CONTAINING CYCLOBUTANE, ESTER, AZINE, OR HYDRAZIDE GROUPS

被引：1

作者：

Ishmuratov, G. Yu. ^{[1
]}

Mingaleeva, G. R. ^{[1
]}

Shakhanova, O. O. ^{[1
]}

Muslukhov, R. R. ^{[1
]}

Yakovleva, M. P. ^{[1
]}

Botsman, L. P. ^{[1
]}

Tolstikov, A. G. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2011年 / 47卷 / 02期

关键词：

(+)-alpha-pinene; 1 '-[(1S,3S)-3-(2-hydroxyethyl)-2,2-dimethylcyclobutyl]ethanone; bis{2; '''-[(1; S; 3; S)-3; '-acetyl-2; 2; '-dimethylcyclobutyl]ethyl}pentanedioate; '-dimethylcyclobutyl]ethyl}hexanedioate; optically active macrocyclic azinodiesters and diesterdihydrazides; synthesis; DERIVATIVES;

D O I：

10.1007/s10600-011-9884-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optically active symmetric macrocyclic diesterazines and diesterdihydrazides were synthesized efficiently from the available natural monoterpene (+)-alpha-pinene (de 50%) using a [2+1]-reaction of 1'-[(1S, 3S)-3-(2-hydroxyethyl)- 2,2- dimethylcyclobutyl]ethanone and glutaric and adipic acid chlorides followed by [1+1]condensation of the intermediate diketodiesters with hydrazine hydrate or glutaric acid dihydrazide.

引用

页码：210 / 214

页数：5

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