Metal-containing peptide nucleic acid conjugates

被引：47

作者：

Gasser, Gilles ^{[1
]}

Sosniak, Anna M. ^{[2
]}

Metzler-Nolte, Nils ^{[2
]}

机构：

[1] Univ Zurich, Inst Inorgan Chem, CH-8057 Zurich, Switzerland

[2] Ruhr Univ Bochum, Fac Chem & Biochem, Dept Inorgan Chem Bioinorgan Chem 1, D-44801 Bochum, Germany

来源：

DALTON TRANSACTIONS | 2011年 / 40卷 / 27期

基金：

瑞士国家科学基金会;

关键词：

BREAST-CANCER XENOGRAFTS; ONCOGENE MESSENGER-RNAS; ENHANCED CELLULAR UPTAKE; INTERSTRAND CROSS-LINKS; LABEL-FREE DETECTION; ELECTROCHEMICAL DETECTION; DNA HYBRIDIZATION; ELECTRON-TRANSFER; GENE-EXPRESSION; PNA OLIGOMERS;

D O I：

10.1039/c0dt01706j

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA(center dot)DNA hybrid stability, and last but not least as probes for molecular and cell biology.

引用

页码：7061 / 7076

页数：16

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