Biomarkers in Sepsis

被引：136
作者：
van Engelen, Tjitske S. R. [1 ]
Wiersinga, Willem Joost [1 ,2 ]
Scicluna, Brendon P. [1 ,3 ]
van der Poll, Tom [1 ,2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Div Lab Specialties, Ctr Expt Mol Med, Meibergdreef 9,Room G2-130, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Div Infect Dis, Meibergdreef 9,Room G2-130, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Meibergdreef 9,Room G2-130, NL-1105 AZ Amsterdam, Netherlands
来源：
CRITICAL CARE CLINICS | 2018年 / 34卷 / 01期
关键词：
Sepsis; Biomarkers; Procalcitonin; Omics technologies; Transcriptomics; Diagnosis; Prognosis; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; PROCALCITONIN; MORTALITY; BACTERIAL; INFECTION; OUTCOMES; METABOLOMICS; INFLAMMATION; DIAGNOSIS;
D O I：
10.1016/j.ccc.2017.08.010
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A biomarker is a characteristic by which a (patho) physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (to assign risk profiles and predict outcome), and in the future may be of theranostic value (to aid in the selection and monitoring of therapy). Systems biology provides a promising tool for the discovery of novel biomarkers. Biomarkers can be the key to personalized targeted treatment in the future clinical management of sepsis.
引用
收藏
页码：139 / +
页数：15
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