An Additional Dehydratase-Like Activity is Required for Lankacidin Antibiotic Biosynthesis

被引：16

作者：

Dickschat, Jeroen S. ^{[1
,4
]}

Vergnolle, Olivia ^{[1
,5
]}

Hong, Hui ^{[1
]}

Garner, Stephen ^{[1
]}

Bidgood, Susanna R. ^{[1
]}

Dooley, Hannah C. ^{[1
]}

Deng, Zixin ^{[2
,3
]}

Leadlay, Peter F. ^{[1
]}

Sun, Yuhui ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Wuhan Univ, Minist Educ, Key Lab Combinatory Biosynth & Drug Discovery, Wuhan 430071, Peoples R China

[3] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Organ Chem, D-38106 Braunschweig, Germany

[5] CUNY Brooklyn Coll, Dept Biol, Brooklyn, NY 11210 USA

来源：

CHEMBIOCHEM | 2011年 / 12卷 / 16期

基金：

英国生物技术与生命科学研究理事会;

关键词：

antibiotics; biosynthesis; dehydratase; polyketides; streptomyces; POLYKETIDE SYNTHASES; T-2636; ANTIBIOTICS; CRYSTAL-STRUCTURE; PRODUCT; MECHANISM; DOMAINS; PATHWAY; COMPLEX; FABZ;

D O I：

10.1002/cbic.201100474

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2408 / 2412

页数：5

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