Bioactive Myrsinol Diterpenoids from the Roots of Euphorbia prolifera

被引：41

作者：

Xu, Jing ^{[1
,2
]}

Guo, Yuanqiang ^{[1
,2
]}

Xie, Chunfeng ^{[1
,2
]}

Li, Yushan ^{[3
]}

Gao, Jie ^{[1
,2
]}

Zhang, Tiejun ^{[4
]}

Hou, Wenbin ^{[4
]}

Fang, Lingzhi ^{[1
,2
]}

Gui, Liping ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[4] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

ESTERS; PLANTS;

D O I：

10.1021/np200591h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SYSY cells.

引用

页码：2224 / 2230

页数：7

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