Bioactive Myrsinol Diterpenoids from the Roots of Euphorbia prolifera

被引：41

作者：

Xu, Jing ^{[1
,2
]}

Guo, Yuanqiang ^{[1
,2
]}

Xie, Chunfeng ^{[1
,2
]}

Li, Yushan ^{[3
]}

Gao, Jie ^{[1
,2
]}

Zhang, Tiejun ^{[4
]}

Hou, Wenbin ^{[4
]}

Fang, Lingzhi ^{[1
,2
]}

Gui, Liping ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[4] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

ESTERS; PLANTS;

D O I：

10.1021/np200591h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SYSY cells.

引用

页码：2224 / 2230

页数：7

共 20 条

[1] New diterpenoids from Euphorbia teheranica [J].

Ahmad, VU ;

Jassbi, AR .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (07) :1016-1018

[2] Diterpenoids from Euphorbia pithyusa subsp cupanii [J].

Appendino, G ;

Belloro, E ;

Tron, GC ;

Jakupovic, J ;

Ballero, M .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (10) :1399-1404

[3] Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo [J].

Doo, Ah-Reum ;

Kim, Seung-Nam ;

Park, Ji-Yeon ;

Cho, Ki Ho ;

Hong, Jongki ;

Eun-Kyung, Kim ;

Moon, Sang Kwan ;

Jung, Woo Sang ;

Lee, Hyejung ;

Jung, Jae Han ;

Park, Hi-Joon .

JOURNAL OF ETHNOPHARMACOLOGY, 2010, 131 (02) :433-442

[4] Bioactive neo-Clerodane Diterpenoids from the Whole Plants of Ajuga ciliata Bunge [J].

Guo, Ping ;

Li, Yushan ;

Xu, Jing ;

Liu, Cuizhou ;

Ma, Yonggang ;

Gue, Yuanqiang .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (07) :1575-1583

[5]

HEYWOOD VH, 1998, FLOWERING PLANTS WOR, P183

[6] Chemistry and biological activity of secondary metabolites in Euphorbia from Iran [J].

Jassbi, Amir Reza .

PHYTOCHEMISTRY, 2006, 67 (18) :1977-1984

[7] DITERPENES FROM EUPHORBIA-SEGUIERIANA [J].

JESKE, F ;

JAKUPOVIC, J ;

BERENDSOHN, W .

PHYTOCHEMISTRY, 1995, 40 (06) :1743-1750

[8] New Cytotoxic Myrsinane-Type Diterpenes from Euphorbia prolifera [J].

Li, Jie ;

Xu, Liang ;

Wang, Feng-Peng .

HELVETICA CHIMICA ACTA, 2010, 93 (04) :746-752

[9]

LI Y, 1995, J NAT PRODUCTS, V58, P1883

[10] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

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