Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

被引：28
作者：
Kunzmann, Andrea [1 ]
Dedoussis, George [2 ]
Jajte, Jolanta [3 ]
Malavolta, Marco [4 ]
Mocchegiani, Eugenio [4 ]
Buerkle, Alexander [1 ]
机构：
[1] Univ Konstanz, Mol Toxicol Grp, Dept Biol, Constance, Germany
[2] Harokopio Univ, Dept Nutr Sci & Dietet, Athens, Greece
[3] Med Univ Lodz, Dept Toxicol, Div Toxicol & Food Qual Anal, Lodz, Poland
[4] INRCA, Res Dept, Ctr Immunol, Ancona, Italy
来源：
EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 05期
关键词：
PARP-1; poly(ADP-ribosyl)ation capacity; zinc supplementation; aging;
D O I：
10.1016/j.exger.2007.10.003
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：409 / 414
页数：6
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