Missed Plasmodium falciparum and Plasmodium vivax Mixed Infections in Ethiopia Threaten Malaria Elimination

被引：8

作者：

Leonard, Colleen M. ^{[1
]}

Mohammed, Hussein ^{[2
]}

Tadesse, Mekonnen ^{[3
]}

McCaffery, Jessica N. ^{[1
]}

Nace, Doug ^{[1
]}

Halsey, Eric S. ^{[1
,4
]}

Girma, Samuel ^{[5
]}

Assefa, Ashenafi ^{[2
,6
]}

Hwang, Jimee ^{[1
,4
]}

Rogier, Eric ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA 30329 USA

[2] Ethiopia Publ Hlth Inst, Addis Ababa, Ethiopia

[3] Columbia Univ, ICAP, Addis Ababa, Ethiopia

[4] Ctr Dis Control & Prevent, Malaria Branch, US Presidents Malaria Initiat, Atlanta, GA USA

[5] USAID, US Presidents Malaria Initiat, Addis Ababa, Ethiopia

[6] Univ N Carolina, Infect Dis Ecol & Epidemiol Lab, Chapel Hill, NC 27515 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2022年 / 106卷 / 02期

关键词：

D O I：

10.4269/ajtmh.21-0796

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia. This study investigated whether mixed infections were missed by microscopy from a 2017 therapeutic efficacy study at two health facilities in Ethiopia. All patients (N = 304) were initially classified as having single-species P. falciparum (n = 148 samples) or P. vivax infections (n = 156). Dried blood spots were tested for Plasmodium antigens by bead-based multiplex assay for pan-Plasmodium aldolase, pan-Plasmodium lactate dehydrogenase, P. vivax lactate dehydrogenase, and histidine-rich protein 2. Of 304 blood samples, 13 (4.3%) contained both P. falciparum and P. vivax antigens and were analyzed by polymerase chain reaction for species-specific DNA. Of these 13 samples, five were confirmed by polymerase chain reaction for P. falciparum/P. vivax co-infection. One sample, initially classified as P. vivax by microscopy, was found to only have Plasmodium ovale DNA. Plasmodium falciparum/P. vivax mixed infections can be missed by microscopy even in the context of a therapeutic efficacy study with multiple trained readers.

引用

页码：667 / 670

页数：4

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