Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

被引：164

作者：

Vandooren, Jennifer ^{[1
]}

Itoh, Yoshifumi ^{[2
]}

机构：

[1] Katholieke Univ KU Leuven, Rega Inst Med Res, Dept Microbiol Immunol & Transplantat, Lab Immunobiol, Leuven, Belgium

[2] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

alpha-2-macroglobulin; proteolysis; inflammation; immunity; infections; macrophages; neutrophils; RECEPTOR-RELATED PROTEIN; GROWTH-FACTOR-BETA; ALPHA(2)-MACROGLOBULIN SIGNALING RECEPTOR; PHOSPHOLIPASE A(2) ACTIVITY; MANNAN-BINDING LECTIN; NECROSIS-FACTOR-ALPHA; CELL-SURFACE GRP78; TRYPANOSOMA-CRUZI; TRANSFORMING GROWTH-FACTOR-BETA-1; RECOGNIZED FORMS;

D O I：

10.3389/fimmu.2021.803244

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for endopeptidases of all catalytic types, alpha-2-macroglobulin lures active proteases into its molecular cage and subsequently 'flags' their complex for elimination. In addition to its role as a regulator of extracellular proteolysis, alpha-2-macroglobulin also has other functions such as switching proteolysis towards small substrates, facilitating cell migration and the binding of cytokines, growth factors and damaged extracellular proteins. These functions appear particularly important in the context of immune-cell function. In this review manuscript, we provide an overview of all functions of alpha-2-macroglobulin and place these in the context of inflammation, immunity and infections.

引用

页数：20