Anti-allergic activity of 18β-glycyrrhetinic acid-3-O-β-D-glucuronide

被引：124

作者：

Park, HY

Park, SH

Yoon, HK

Han, MJ

Kim, DH

机构：

[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea

[3] Kyungwon Coll, Dept Human Life Sci, Songnam 461701, Kyonggi Do, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 01期

关键词：

18 beta-glycyrrhetinic acid-3-O-beta-D-glucuronide; glycyrrhizin; streptococcus LJ-22; anti-allergic activity;

D O I：

10.1007/BF02980047

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1-->2)-beta-D-glucuroniae, GL) was transformed to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with IC50 values of 0.28 mM. GAMG, which is sweeter than GL, and 18beta-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.

引用

页码：57 / 60

页数：4

共 15 条

[11] MICROBIAL-PRODUCTION OF GLYCYRRHETIC ACID 3-0-MONO-BETA-D-GLUCURONIDE FROM GLYCYRRHIZIN BY CRYPTOCOCCUS-MAGNUS MG-27 [J].