Biologic Therapies for Severe Asthma

被引：387

作者：

Brusselle, Guy G. ^{[1
,2
]}

Koppelman, Gerard H. ^{[3
,4
]}

机构：

[1] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[2] Erasmus MC, Dept Epidemiol & Resp Med, Rotterdam, Netherlands

[3] Univ Groningen, Dept Pediat Pulmonol & Pediat Allergol, Beatrix Childrens Hosp, Univ Med Ctr Groningen, Groningen, Netherlands

[4] Univ Groningen, Groningen Res Inst Asthma & COPD, Univ Med Ctr Groningen, Groningen, Netherlands

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 386卷 / 02期

关键词：

SEVERE EOSINOPHILIC ASTHMA; QUALITY-OF-LIFE; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; PRECISION MEDICINE; NASAL POLYPOSIS; MEPOLIZUMAB; PLACEBO; BENRALIZUMAB; EFFICACY;

D O I：

10.1056/NEJMra2032506

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may be required to reduce the disease burden. This review discusses the mechanisms, efficacy, and safety of biologics for severe asthma.

引用

页码：157 / 171

页数：15

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