Citicoline and COVID-19: vis-a-vis conjectured

被引：13
作者：
Al-kuraishy, Hayder M. [1 ]
Al-Buhadily, Ali K. [1 ]
Al-Gareeb, Ali I. [1 ]
Alorabi, Mohammed [2 ]
Hadi Al-Harcan, Nasser A. [3 ]
El-Bouseary, Maisra M. [4 ]
Batiha, Gaber El-Saber [5 ]
机构：
[1] Al Mustansiriya Univ, Dept Clin Pharmacol & Med, Coll Med, Baghdad, Iraq
[2] Taif Univ, Dept Biotechnol, Coll Sci, POB 11099, Taif 21944, Saudi Arabia
[3] Al Rasheed Univ Coll, Dept Clin Pharmacol & Med, Coll Med, Baghdad, Iraq
[4] Tanta Univ, Dept Pharmaceut Microbiol, Fac Pharm, Tanta, Egypt
[5] Damanhour Univ, Dept Pharmacol & Therapeut, Fac Vet Med, Albeheira 22511, Damanhour, Egypt
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2022年 / 395卷 / 12期
关键词：
COVID-19; Neuroinflammation; Citicoline; SARS-CoV-2; ACUTE ISCHEMIC-STROKE; NEUROLOGICAL MANIFESTATIONS; ACTIVATION; METAANALYSIS; DISORDERS; MECHANISM; SEVERITY; THERAPY; DISEASE; SYSTEM;
D O I：
10.1007/s00210-022-02284-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Coronavirus disease 2019 (COVID-19) is a current pandemic disease caused by a novel severe acute respiratory syndrome coronavirus virus respiratory type 2 (SARS-CoV-2). SARS-CoV-2 infection is linked with various neurological manifestations due to cytokine-induced disruption of the blood brain barrier (BBB), neuroinflammation, and peripheral neuronal injury, or due to direct SARS-CoV-2 neurotropism. Of note, many repurposed agents were included in different therapeutic protocols in the management of COVID-19. These agents did not produce an effective therapeutic eradication of SARS-CoV-2, and continuing searching for novel anti-SARS-CoV-2 agents is a type of challenge nowadays. Therefore, this study aimed to review the potential anti-inflammatory and antioxidant effects of citicoline in the management of COVID-19.
引用
收藏
页码：1463 / 1475
页数：13
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