A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

被引：566
作者：
Singh, Namrata [1 ,2 ,3 ]
Savanur, Mohammed Azharuddin [2 ]
Srivastava, Shubhi [2 ]
D'Silva, Patrick [2 ]
Mugesh, Govindasamy [1 ]
机构：
[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India
[2] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India
[3] Indian Inst Sci, Ctr Nanosci & Engn, Bangalore 560012, Karnataka, India
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 45期
关键词：
biomimetic chemistry; enzyme catalysis; manganese; nanocatalysis; nanozymes; C-H BOND; SELECTIVE TRANSFER HYDROGENATION; CROSS-COUPLING REACTIONS; MILD CONDITIONS; N-HETEROAROMATICS; ALPHA-ALKYLATION; PRIMARY ALCOHOLS; TERTIARY-AMINES; CYCLIC AMINES; BENZOIC-ACIDS;
D O I：
10.1002/anie.201708573
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphologydependent. The redox modulatory effect of Mn3O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multienzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
引用
收藏
页码：14267 / 14271
页数：5
相关论文
共 72 条
[11]   A Molecular Iron Catalyst for the Acceptorless Dehydrogenation and Hydrogenation of N-Heterocycles [J].
Chakraborty, Sumit ;
Brennessel, William W. ;
Jones, William D. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (24) :8564-8567
[12]  
Chen Z., 2015, ANGEW CHEM, V127, P14695
[13]   Formal Direct Cross-Coupling of Phenols with Amines [J].
Chen, Zhengwang ;
Zeng, Huiying ;
Girard, Simon A. ;
Wang, Feng ;
Chen, Ning ;
Li, Chao-Jun .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (48) :14487-14491
[14]   Palladium-catalyzed reductive coupling of phenols with anilines and amines: efficient conversion of phenolic lignin model monomers and analogues to cyclohexylamines [J].
Chen, Zhengwang ;
Zeng, Huiying ;
Gong, Hang ;
Wang, Haining ;
Li, Chao-Jun .
CHEMICAL SCIENCE, 2015, 6 (07) :4174-4178
[15]   General and Mild Cobalt-Catalyzed C-Alkylation of Unactivated Amides and Esters with Alcohols [J].
Deibl, Nicklas ;
Kempe, Rhett .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (34) :10786-10789
[16]   Iridium-Catalyzed Hydrogenation of N-Heterocyclic Compounds under Mild Conditions by an Outer-Sphere Pathway [J].
Dobereiner, Graham E. ;
Nova, Ainara ;
Schley, Nathan D. ;
Hazari, Nilay ;
Miller, Scott J. ;
Eisenstein, Odile ;
Crabtree, Robert H. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (19) :7547-7562
[17]   Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis [J].
Dobereiner, Graham E. ;
Crabtree, Robert H. .
CHEMICAL REVIEWS, 2010, 110 (02) :681-703
[18]  
Elangovan S., 2015, Angew. Chem., V127, P14691
[19]   Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes [J].
Elangovan, Saravanakumar ;
Neumann, Jacob ;
Sortais, Jean-Baptiste ;
Junge, Kathrin ;
Darcel, Christophe ;
Beller, Matthias .
NATURE COMMUNICATIONS, 2016, 7
[20]   Iron-Catalyzed α-Alkylation of Ketones with Alcohols [J].
Elangovan, Saravanakumar ;
Sortais, Jean-Baptiste ;
Beller, Matthias ;
Darcel, Christophe .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (48) :14483-14486
12345678