A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

被引：561

作者：

Singh, Namrata ^{[1
,2
,3
]}

Savanur, Mohammed Azharuddin ^{[2
]}

Srivastava, Shubhi ^{[2
]}

D'Silva, Patrick ^{[2
]}

Mugesh, Govindasamy ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

[3] Indian Inst Sci, Ctr Nanosci & Engn, Bangalore 560012, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 45期

关键词：

biomimetic chemistry; enzyme catalysis; manganese; nanocatalysis; nanozymes; C-H BOND; SELECTIVE TRANSFER HYDROGENATION; CROSS-COUPLING REACTIONS; MILD CONDITIONS; N-HETEROAROMATICS; ALPHA-ALKYLATION; PRIMARY ALCOHOLS; TERTIARY-AMINES; CYCLIC AMINES; BENZOIC-ACIDS;

D O I：

10.1002/anie.201708573

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphologydependent. The redox modulatory effect of Mn3O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multienzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.

引用

页码：14267 / 14271

页数：5

共 72 条

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[3]

[Anonymous], 2016, ANGEW CHEM

[4]

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