No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort

被引：16

作者：

Fernandez-Santiago, Ruben ^{[1
,2
]}

Sharma, Manu ^{[1
]}

Berg, Daniela ^{[1
]}

Illig, Thomas ^{[3
]}

Anneser, Johanna ^{[4
]}

Meyer, Thomas ^{[5
]}

Ludolph, Albert ^{[6
]}

Gasser, Thomas ^{[1
]}

机构：

[1] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Disorders, D-72076 Tubingen, Germany

[2] Univ Tubingen, Grad Training Ctr Neurosci, Int Max Planck Res Sch, Grad Sch Cellular & Mol Neurosci, D-72076 Tubingen, Germany

[3] GSF Natl Res Ctr Environm & Hlth, Inst Epidemiol, Neuherberg, Germany

[4] Univ Munich, Dept Neurol, Grosshadern Univ Hosp, D-8000 Munich, Germany

[5] Charite Humbolt Univ Hosp Berlin, Dept Neurol, Berlin, Germany

[6] Univ Hosp Ulm, Dept Neurol, Ulm, Germany

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 03期

关键词：

Amyotrophic lateral sclerosis (ALS); Genome-wide association study (GWAS); Single nucleotide polymorphism (SNP); AMYOTROPHIC-LATERAL-SCLEROSIS; SINGLE-NUCLEOTIDE POLYMORPHISMS; WHOLE-GENOME ASSOCIATION; WIDE ASSOCIATION; SUSCEPTIBILITY GENE; PARKINSON-DISEASE; POPULATION; TCF7L2;

D O I：

10.1016/j.neurobiolaging.2009.04.018

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A recent genome-wide association study (GWAS) found significant association of six single nucleotide polymorphisms (SNPs) in the gene FLJ10986 with sporadic amyotrophic lateral sclerosis (SALS). Another independent GWAS reported significant association of one SNP in the gene inositol 1,4,5-triphosphate receptor 2 (ITPR2) with SALS. These studies provided conflicting results. We examined the six most significant SNPs in FLJ10986 and one SNP in ITPR2 in a large cohort consisting of 595 SALS cases and 681 controls ascertained from Germany. Our results did not provide evidence for the association of these SNPs with SALS, suggesting a possible population-specific effect for FLJ10986 and ITPR2 that do not modulate the risk for SALS in the German population. (C) 2009 Published by Elsevier Inc.

引用

页码：551.e1 / 551.e4

页数：4

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