Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Aerobic Exercise on the Recovery of Motor Function in Ischemic Stroke Rat Model

被引:23
|
作者
Cui, Juanxiu [1 ]
Kim, Cuk-Seong [2 ]
Kim, Yeongwook [3 ]
Sohn, Min Kyun [1 ,3 ]
Jee, Sungju [3 ]
机构
[1] Chungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon 35015, South Korea
[2] Chungnam Natl Univ, Dept Physiol & Med Sci, Coll Med, Daejeon 35015, South Korea
[3] Chungnam Natl Univ Hosp, Dept Rehabil Med, Daejeon 35015, South Korea
基金
新加坡国家研究基金会;
关键词
transcranial magnetic stimulation; exercise; neuroplasticity; function recovery; middle cerebral artery occlusion; CEREBRAL-ARTERY OCCLUSION; BRAIN-DAMAGE; EXCITABILITY; DISEASE; BDNF;
D O I
10.3390/brainsci10030186
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The therapeutic benefits of repetitive transcranial magnetic stimulation (rTMS) combined with rehabilitation therapy on recovery after stroke have not been fully elucidated. This study aimed to explore the therapeutic effects of rTMS followed by aerobic exercise on neuroplasticity and recovery of motor function in a rat model of permanent middle cerebral artery occlusion (MCAO). Rats were randomized into sham operation (N = 10, sham op), MCAO (N = 10, control group), rTMS (N = 10, MCAO and rTMS therapy), and combination groups (N = 10, MCAO and combination therapy). High-frequency rTMS (10 Hz) was applied on the ipsilesional forepaw motor cortex, and aerobic exercise training on the rotarod was performed for two weeks. The rotarod and Garcia tests were conducted to evaluate changes in behavioral function. Motor evoked potentials (MEPs) were used to evaluate electrophysiological changes. Stroke severity was assessed using infarction volume measurement. Neuronal recovery was explored with western blot for brain-derived neurotrophic factor (BDNF) pathway proteins. Compared with control therapy, combination therapy was significantly more effective than rTMS therapy for improving function on the rotarod test (p = 0.08), Garcia test (p = 0.001), and MEP amplitude (p = 0.001) In conclusion, combination therapy may be a potential treatment to promote recovery of motor function and neuroplasticity in stroke patients.
引用
收藏
页数:13
相关论文
共 50 条
  • [41] Combining aerobic exercise and repetitive transcranial magnetic stimulation to improve brain function in health and disease
    Hendrikse, Joshua
    Kandola, Aaron
    Coxon, James
    Rogasch, Nigel
    Yucel, Murat
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2017, 83 : 11 - 20
  • [42] THE EFFECT OF SCALP ACUPUNCTURE AND REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEUROMOTOR FUNCTION IN PHOTOTHROMBOTIC STROKE RAT MODEL
    Lee, Sam-Gyu
    Kim, Eun-Jong
    Selenge, Ganbold
    MUSCLE & NERVE, 2016, 54 (03) : 553 - 553
  • [43] Effects of Repetitive Transcranial Magnetic Stimulation on Pallidum GABAergic Neurons and Motor Function in Rat Models of Kernicterus
    Wang, Nanqin
    Jia, Yongzhu
    Zhou, Xuanzi
    Wang, Xia
    Zhou, Huyao
    Xiao, Nong
    BRAIN SCIENCES, 2023, 13 (09)
  • [44] Effect of electroacupuncture combined with repetitive transcranial magnetic stimulation on limb dysfunction in patients with ischemic stroke
    Zhao, Yiling
    Xu, Yuemei
    Wang, Chuanjie
    Qiu, Mulei
    Chen, Benmei
    Pan, Danqing
    JOURNAL OF ACUPUNCTURE AND TUINA SCIENCE, 2024, 22 (06) : 454 - 461
  • [45] Effects of repetitive transcranial magnetic stimulation combined with functional electrical stimulation on hand function of stroke: A randomized controlled trial
    Yang, Zhen
    Qiao, Linru
    He, Jianhua
    Zhao, Xue
    Zhang, Minyan
    NEUROREHABILITATION, 2022, 51 (02) : 283 - 289
  • [46] Treatment effects of low-frequency repetitive transcranial magnetic stimulation combined with motor relearning procedure on spasticity and limb motor function in stroke patients
    Chen, Ruijun
    Zhang, Yu
    Wang, Xiaocheng
    Zhao, Yunfei
    Fan, Shasha
    Xue, Yanping
    Zhao, Jing
    Liu, Yinlian
    Wang, Pingzhi
    FRONTIERS IN NEUROLOGY, 2023, 14
  • [47] High-frequency repetitive transcranial magnetic stimulation promotes ipsilesional functional hyperemia and motor recovery in mice with ischemic stroke
    Liu, Li
    Ding, Ming
    Wu, Junfa
    Zhang, Yuwen
    Wang, Qianfeng
    Wang, Nianhong
    Luo, Lu
    Yu, Kewei
    Fan, Yunhui
    Zhang, Jingjun
    Wu, Yi
    Xiao, Xiao
    Zhang, Qun
    CEREBRAL CORTEX, 2024, 34 (03)
  • [48] Role of 1 and 3 Hz repetitive transcranial magnetic stimulation on motor function recovery after acute ischaemic stroke
    Khedr, E. M.
    Abdel-Fadeil, M. R.
    Farghali, A.
    Qaid, M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 (12) : 1323 - 1330
  • [49] Effects of 10 Hz High Frequency Repetitive Transcranial Magnetic Stimulation Combined with Somatosensory Training for Recovery of Upper Limb Motor and Hand Function in Chronic Stroke Patients
    Jeong, Jung-Woo
    Han, Man-Seok
    Song, Bo-Kyoung
    JOURNAL OF MAGNETICS, 2020, 25 (04) : 691 - 696
  • [50] Effects of Motor Imagery Practice in Conjunction with Repetitive Transcranial Magnetic Stimulation on Stroke Patients
    Ji, Sang-Goo
    Cha, Hyun-Gyu
    Kim, Ki-Jong
    Kim, Myoung-Kwon
    JOURNAL OF MAGNETICS, 2014, 19 (02) : 181 - 184