Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Aerobic Exercise on the Recovery of Motor Function in Ischemic Stroke Rat Model
被引:23
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作者:
Cui, Juanxiu
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机构:
Chungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon 35015, South KoreaChungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon 35015, South Korea
Cui, Juanxiu
[1
]
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Kim, Cuk-Seong
[2
]
Kim, Yeongwook
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机构:
Chungnam Natl Univ Hosp, Dept Rehabil Med, Daejeon 35015, South KoreaChungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon 35015, South Korea
Kim, Yeongwook
[3
]
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Sohn, Min Kyun
[1
,3
]
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Jee, Sungju
[3
]
机构:
[1] Chungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon 35015, South Korea
[2] Chungnam Natl Univ, Dept Physiol & Med Sci, Coll Med, Daejeon 35015, South Korea
[3] Chungnam Natl Univ Hosp, Dept Rehabil Med, Daejeon 35015, South Korea
transcranial magnetic stimulation;
exercise;
neuroplasticity;
function recovery;
middle cerebral artery occlusion;
CEREBRAL-ARTERY OCCLUSION;
BRAIN-DAMAGE;
EXCITABILITY;
DISEASE;
BDNF;
D O I:
10.3390/brainsci10030186
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The therapeutic benefits of repetitive transcranial magnetic stimulation (rTMS) combined with rehabilitation therapy on recovery after stroke have not been fully elucidated. This study aimed to explore the therapeutic effects of rTMS followed by aerobic exercise on neuroplasticity and recovery of motor function in a rat model of permanent middle cerebral artery occlusion (MCAO). Rats were randomized into sham operation (N = 10, sham op), MCAO (N = 10, control group), rTMS (N = 10, MCAO and rTMS therapy), and combination groups (N = 10, MCAO and combination therapy). High-frequency rTMS (10 Hz) was applied on the ipsilesional forepaw motor cortex, and aerobic exercise training on the rotarod was performed for two weeks. The rotarod and Garcia tests were conducted to evaluate changes in behavioral function. Motor evoked potentials (MEPs) were used to evaluate electrophysiological changes. Stroke severity was assessed using infarction volume measurement. Neuronal recovery was explored with western blot for brain-derived neurotrophic factor (BDNF) pathway proteins. Compared with control therapy, combination therapy was significantly more effective than rTMS therapy for improving function on the rotarod test (p = 0.08), Garcia test (p = 0.001), and MEP amplitude (p = 0.001) In conclusion, combination therapy may be a potential treatment to promote recovery of motor function and neuroplasticity in stroke patients.
机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Chen, Ruijun
Zhang, Yu
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机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Tradit Chinese Med, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Tradit Chinese Med, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Zhang, Yu
Wang, Xiaocheng
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机构:
Shanxi Prov Peoples Hosp, Dept Med Record & Stat, Taiyuan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Wang, Xiaocheng
Zhao, Yunfei
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机构:
Shanxi Med Univ, Coll Sports Rehabil, Jinzhong, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Zhao, Yunfei
Fan, Shasha
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机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Fan, Shasha
Xue, Yanping
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h-index: 0
机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Xue, Yanping
Zhao, Jing
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h-index: 0
机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Med Record Management, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Med Record Management, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Zhao, Jing
Liu, Yinlian
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h-index: 0
机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Liu, Yinlian
Wang, Pingzhi
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机构:
Shanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil, Wuhan, Peoples R ChinaShanxi Med Univ, Shanxi Bethune Hosp,Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Rehabil, Taiyuan, Peoples R China