International validation of the EORTC QLQ-CLL17 questionnaire for assessment of health-related quality of life for patients with chronic lymphocytic leukaemia

被引：10

作者：

Oerlemans, Simone ^{[1
]}

Efficace, Fabio ^{[2
]}

Kieffer, Jacobien M. ^{[3
]}

Kyriakou, Charalampia ^{[4
]}

Xochelli, Aliki ^{[5
]}

Levedahl, Kerstin ^{[6
]}

Petranovic, Duska ^{[7
]}

Borges, Fabio Cardoso ^{[8
,9
]}

Bredart, Anne ^{[10
,11
]}

Shamieh, Omar ^{[12
]}

Gziskevicius, Laimonas ^{[13
]}

Lehmann, Jens ^{[14
]}

Scholz, Christian W. ^{[15
]}

Caocci, Giovanni ^{[16
]}

Molica, Stefano ^{[17
]}

Stamatopoulos, Kostas ^{[5
]}

Panteliadou, Alkistis-Kyra ^{[18
,19
]}

Papaioannou, Maria ^{[20
]}

Alrjoob, Waleed ^{[12
]}

Baliakas, Panagiotis ^{[6
]}

Rosenquist, Richard ^{[21
,22
]}

Malak, Sandra ^{[23
]}

Miranda, Ana ^{[8
,9
]}

Cocks, Kim ^{[24
,25
]}

van de Poll-Franse, Lonneke ^{[1
,3
,26
]}

机构：

[1] Netherlands Comprehens Canc Org IKNL, Dept Res & Dev, Utrecht, Netherlands

[2] Italian Grp Adult & Hematol Dis GIMEMA, Data Ctr, Hlth Outcomes Res Unit, Rome, Italy

[3] Netherlands Canc Inst, Dept Psychosocial Res & Epidemiol, Amsterdam, Netherlands

[4] Univ Coll London Hosp, London, England

[5] Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece

[6] Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Uppsala, Sweden

[7] Univ Rijeka, Clin Hosp Ctr Rijeka, Rijeka, Croatia

[8] Inst Portugues Oncol Lisboa Francisco Gentil &, EPE, Dept Epidemiol, Lisbon, Portugal

[9] Inst Portugues Oncol Lisboa Francisco Gentil &, EPE, Natl Canc Registry RON, Lisbon, Portugal

[10] Paris Univ, Inst Curie, Psychooncol Unit, Paris, France

[11] PSL Univ, Psychopathol & Hlth Proc Lab LPPS, UR 4057, Paris, France

[12] King Hussein Canc Ctr, Dept Palliat Med, Amman, Jordan

[13] Univ Hosp, Vilnius, Lithuania

[14] Med Univ Innsbruck, Univ Hosp Psychiat 2, Innsbruck, Austria

[15] Vivantes Klinikum Urban, Hematol & Oncol, Berlin, Germany

[16] Univ Cagliari, Businco Hosp, Hematol, Cagliari, Italy

[17] Azienda Ospedalier Ciaccio, Catanzaro, Italy

[18] G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece

[19] G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece

[20] AHEPA Hosp, AUTH, Dept Internal Med 1, Hematol Unit, Thessaloniki, Greece

[21] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden

[22] Karolinska Univ Hosp, Clin Genet, Stockholm, Sweden

[23] Hop Rene Huguenin, Inst Curie Hematol, St Cloud, France

[24] Univ York, York Trials Unit, York, N Yorkshire, England

[25] Adelphi Values, Bollington, Cheshire, England

[26] Tilburg Univ, Dept Med & Clin Psychol, Tilburg, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2022年 / 197卷 / 04期

关键词：

chronic lymphocytic leukaemia; EORTC; PRO; psychometric properties; quality of life; questionnaire; symptoms; REPORTED OUTCOMES; CHLORAMBUCIL; THERAPY; QLQ-C30; RITUXIMAB; LYMPHOMA; CRITERIA; TRIALS; FEAR;

D O I：

10.1111/bjh.18072

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Selecting the most appropriate chronic lymphocytic leukaemia (CLL) treatment is challenging. Patient-reported health-related quality of life (HRQoL) is therefore a critical aspect to consider. This international study by the European Organization for Research and Treatment of Cancer (EORTC) tested the psychometric properties of a newly developed measure for CLL patients: the EORTC QLQ-CLL17 to supplement the core questionnaire (EORTC QLQ-C30). Patients with CLL (n = 341) from 12 countries completed the QLQ-C30, QLQ-CLL17 and a debriefing questionnaire. Sociodemographic and clinical data were recorded from medical records. A high percentage (30%-66%) reported symptoms and/or worries (e.g. aches/pains in muscles, lack of energy and worry/fears about health). Confirmatory factor analysis showed an acceptable to good fit of the 17 items on the three scales (i.e. symptom burden, physical condition/fatigue and worries/fears about health and functioning). Completion took on average 8 min. Test-retest and convergent validity was demonstrated. The QLQ-CLL17 differentiated between patients with an Eastern Cooperative Oncology group (ECOG) performance of 0 versus 1-3 (p's < 0.01 and clinically relevant). The newly developed EORTC QLQ-CLL17 will increase sensitivity of HRQoL assessment in patients with CLL. Implementation of this questionnaire both in clinical research and practice will help to generate unique clinically relevant data to better inform CLL treatment decision-making.

引用

页码：431 / 441

页数：11

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