Mass spectrometric strategies: providing structural clues for helminth glycoproteins

被引：31

作者：

Haslam, SM ^{[1
]}

Morris, HR ^{[1
]}

Dell, A ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AY, England

来源：

TRENDS IN PARASITOLOGY | 2001年 / 17卷 / 05期

关键词：

D O I：

10.1016/S1471-4922(00)01860-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Here we review current knowledge of helminth glycans and introduce parasitologists to the power of the mass spectrometric techniques that have been largely responsible for defining their carbohydrate moieties. A brief overview of glycosylation in other eukaryotes is presented, with a focus on mammalian glycosylation, to facilitate understanding of how parasite structures might be recognized as 'self' or 'foreign' by the immune system of the host.

引用

页码：231 / 235

页数：5

共 25 条

[1] Schistosome glycoconjugates [J].

Cummings, RD ;

Nyame, AK .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1455 (2-3) :363-374

[2] Immunogenic glycoconjugates implicated in parasitic nematode diseases [J].

Dell, A ;

Haslam, SM ;

Morris, HR ;

Khoo, KH .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1455 (2-3) :353-362

[3] Regulation of schistosome egg granuloma formation: Host-soluble L-selectin enters tissue-trapped eggs and binds to carbohydrate antigens on surface membranes of miracidia [J].

ElRidi, R ;

Velupillai, P ;

Harn, DA .

INFECTION AND IMMUNITY, 1996, 64 (11) :4700-4705

[4] Haemonchus contortus glycoproteins contain N-linked oligosaccharides with novel highly fucosylated core structures [J].

Haslam, SM ;

Coles, GC ;

Munn, EA ;

Smith, TS ;

Smith, HF ;

Morris, HR ;

Dell, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (48) :30561-30570

[5] Structural studies of N-glycans of filarial parasites -: Conservation of phosphorylcholine-substituted glycans among species and discovery of novel chito-oligomers [J].

Haslam, SM ;

Houston, KM ;

Harnett, W ;

Reason, AJ ;

Morris, HR ;

Dell, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :20953-20960

[6] Structural characterization of the N-glycans of Dictyocaulus viviparus:: discovery of the Lewisx structure in a nematode [J].

Haslam, SM ;

Coles, GC ;

Morris, HR ;

Dell, A .

GLYCOBIOLOGY, 2000, 10 (02) :223-229

[7] The novel core fucosylation of Haemonchus contortus N-glycans is stage specific [J].

Haslam, SM ;

Coles, GC ;

Reason, AJ ;

Morris, HR ;

Dell, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 93 (01) :143-147

[8] Characterisation of the phosphorylcholine-containing N-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae [J].

Haslam, SM ;

Khoo, KH ;

Houston, KM ;

Harnett, W ;

Morris, HR ;

Dell, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 85 (01) :53-66

[9] Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation [J].

Jacobs, W ;

Deelder, A ;

Van Marck, E .

PARASITOLOGY RESEARCH, 1999, 85 (01) :14-18

[10]

KHOO K-H, 1991, Glycobiology, V1, P163, DOI 10.1093/glycob/1.2.163

← 1 2 3 →