Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor

被引:10
作者
Chen, Qichao [1 ]
Xiong, Lixia [2 ]
Luo, Min [1 ]
Wang, Jin [1 ]
Hu, Changyan [1 ]
Zhang, Xiao [2 ]
Yu, Shujing [2 ]
Li, Yonghong [2 ]
Sun, Dequn [1 ]
机构
[1] Shandong Univ Weihai, Marine Coll, Weihai 264209, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
关键词
INSECTICIDAL ACTIVITIES; BIOLOGICAL EVALUATION; ANTHRANILIC DIAMIDES; RESISTANCE; GENETICS; CHANNEL; AMIDES;
D O I
10.3390/molecules20033854
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In order to identify novel chlorantraniliprole derivatives as potential insecticides or fungicides, 25 analogues of chlorantraniliprole were synthesized. The insecticidal activities against oriental armyworm and the antifungal activities against five typical fungi of these derivatives were tested. Compounds 2u, 2x and 2y exhibited good activities against oriental armyworm, especially compounds 2u and 2x which showed higher larvicidal activities than indoxacarb. Moreover, all of the tested compounds exhibited activities against five typical fungi. The Ki values of all synthesized compounds were calculated using AutoDock4. The relationship between the Ki values and the results of insecticidal activities against oriental armyworm further indicated that the membrane-spanning domain protein of the ryanodine receptor might contain chlorantraniliprole binding sites.
引用
收藏
页码:3854 / 3867
页数:14
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