Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus

被引：43

作者：

Yoshioka, Tomokazu ^{[1
]}

Mishima, Hajime ^{[1
]}

Akaogi, Hiroshi ^{[1
]}

Sakai, Shinsuke ^{[1
]}

Li, Meihua ^{[1
]}

Ochiai, Naoyuki ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Orthopaed Surg, Tsukuba, Ibaraki 3058575, Japan

来源：

INTERNATIONAL ORTHOPAEDICS | 2011年 / 35卷 / 06期

关键词：

AVASCULAR NECROSIS; CELLS; HIP;

D O I：

10.1007/s00264-010-1048-y

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The purpose of this study was to evaluate concentrated autologous bone marrow aspirate transplantation (CABMAT) treatment for corticosteroid-induced osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Bone marrow was aspirated from iliac crests, concentrated on a conventional manual blood bag centrifugation technique that is used to extract buffy coats and then injected into nine hips with drilling. The mean number of nucleated cells for transplantation was 5.32 x 10(7) cells/ml. This cell concentration was significantly higher after concentration, and the mean concentration ratio was 5.5. At follow-up (minimum: three years), significant improvement in pain and Harris Hip Score was observed. For eight of nine hips, we successfully preserved the femoral head. However, one hip required total hip arthroplasty 45 months after the operation. CABMAT using our centrifugation technique is an effective, safe and low-cost procedure of therapeutic osteogenesis for corticosteroid-induced ONFH in SLE.

引用

页码：823 / 829

页数：7

共 21 条

[1] Osteonecrosis in patients with SLE [J].