Allergenicity assessment of genetically modified crops - what makes sense?

被引：130

作者：

Goodman, Richard E. ^{[1
]}

Vieths, Stefan ^{[2
]}

Sampson, Hugh A. ^{[3
]}

Hill, David ^{[4
]}

Ebisawa, Motohiro ^{[5
]}

Taylor, Steve L. ^{[1
]}

van Ree, Ronald ^{[6
]}

机构：

[1] Univ Nebraska, Dept Food Sci & Technol, Lincoln, NE 68583 USA

[2] Paul Ehrlich Inst, Dept Allergol, D-63225 Langen, Germany

[3] Mt Sinai Med Ctr, Div Pediat Allergy & Immunol, New York, NY 10029 USA

[4] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[5] Natl Sagamihara Hosp, Div Pediat Allergy, Sagamihara, Kanagawa 2288522, Japan

[6] Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE BIOTECHNOLOGY | 2008年 / 26卷 / 01期

关键词：

D O I：

10.1038/nbt1343

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

GM crops have great potential to improve food quality, increase harvest yields and decrease dependency on certain chemical pesticides. Before yields and decrease dependency on certain chemical Before entering the market their safety needs to be This includes a detailed analysis of allergenic risks, safety of allergic consumers has high priority. However, tests currently being applied to assessing allergenicity a sound scientific basis. Recent events with transgenic reveal the fallacy of applying such tests to GM crops.

引用

页码：73 / 81

页数：9

共 56 条

[41] Food allergy - accurately identifying clinical reactivity
Sampson, HA
[J]. ALLERGY, 2005, 60 : 19 - 24
[42] Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein
Sancho, AI
Foxall, R
Rigby, NM
Browne, T
Zuidmeer, L
van Ree, R
Waldron, KW
Mills, ENC
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (14) : 5098 - 5104
[43] Effect of postharvest storage on the expression of the apple allergen Mal d 1
Sancho, Ana I.
Foxall, Robert
Browne, Tom
Dey, Rickmer
Zuidmeer, Laurian
Marzban, Gorji
Waldron, Keith W.
Van Ree, Ronald
Hoffmann-Sommergruber, Karin
Laimer, Margit
Mills, E. N. Clare
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (16) : 5917 - 5923
[44] The value of short amino acid sequence matches for prediction of protein allergenicity
Silvanovich, A
Nemeth, MA
Song, P
Herman, R
Tagliani, L
Bannon, GA
[J]. TOXICOLOGICAL SCIENCES, 2006, 90 (01) : 252 - 258
[45] Safety assessment by in vitro digestibility and allergenicity of genetically modified maize with an amaranth 11S globulin
Sinagawa-García, SR
Rascón-Cruz, Q
Valdez-Ortiz, A
Medina-Godoy, S
Escobar-Gutiérrez, A
Paredes-López, O
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (09) : 2709 - 2714
[46] Allergenicity prediction by protein sequence
Stadler, MB
Stadler, BM
[J]. FASEB JOURNAL, 2003, 17 (06) : 1141 - +
[47] A comparative study of the allergenic potency of wild-type and glyphosate-tolerant gene-modified soybean cultivars
Sten, E
Skov, PS
Andersen, SB
Torp, AM
Olesen, A
Bindslev-Jensen, U
Poulsen, LK
Bindslev-Jensen, C
[J]. APMIS, 2004, 112 (01) : 21 - 28
[48] Review of the development of methodology for evaluating the human allergenic potential of novel proteins
Taylor, Steve L.
[J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2006, 50 (07) : 604 - 609
[49] A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins
Thomas, K
Aalbers, M
Bannon, GA
Bartels, M
Dearman, RJ
Esdaile, DJ
Fu, TJ
Glatt, CM
Hadfield, N
Hatzos, C
Hefle, SL
Heylings, JR
Goodman, RE
Henry, B
Herouet, C
Holsapple, M
Ladics, GS
Landry, TD
MacIntosh, SC
Rice, EA
Privalle, LS
Steiner, HY
Teshima, R
van Ree, R
Woolhiser, M
Zawodny, J
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2004, 39 (02) : 87 - 98
[50] The effects of gastric digestion on codfish allergenicity
Untersmayr, E
Poulsen, LK
Platzer, MH
Pedersen, MH
Boltz-Nitulescu, G
Skov, PS
Jensen-Jarolim, E
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (02) : 377 - 382

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