+276G>T Single Nucleotide Polymorphism in the Adiponectine (APM1) Gene in Donors from the Kharkiv Population

被引：0
作者：
Atramentova, L. A. [1 ]
Poltorak, V. V. [1 ]
Tyzhnenko, T. V. [1 ]
Gorshunskaya, M. Yu. [2 ]
Pochernyaev, A. R. [1 ]
机构：
[1] Ukrainian Acad Sci, Danilevskii Inst Problems Endocrine Pathol, Kharkov, Ukraine
[2] Kharkiv Med Acad Postgrad Educ, Kharkov, Ukraine
来源：
CYTOLOGY AND GENETICS | 2010年 / 44卷 / 06期
关键词：
INSULIN-RESISTANCE SYNDROME; IMPAIRED GLUCOSE-TOLERANCE; ENCODING ADIPONECTIN; METABOLIC SYNDROME; PROXIMAL PROMOTER; ASSOCIATION; RISK; CAUCASIANS; OBESITY; FAMILY;
D O I：
10.3103/S009545271006006X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
+276G > T polymorphism in the adiponectine gene (APM1) was studied in 103 samples obtained from donors in the Kharkiv population (men/women: 64/38; 70 Ukrainian, 33 Russian). The T- and G-allele frequencies did not significantly differ between either men and women or between Russians and Ukrainians and comprised p(T) = 0.55 and p(G) = 0.45 in the general group. The genotype distribution deviated from the Hardy-Weinberg equilibrium: the heterozygote frequency was 1.55 times higher compared to the selectively neutral value, while the TT- and GG- homozygote frequencies were 0.55 and 0.33 of the equilibrium value, respectively.
引用
收藏
页码：361 / 364
页数：4
相关论文
共 26 条
[1]   Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men [J].
Berthier, MT ;
Houde, A ;
Côté, M ;
Paradis, AM ;
Mauriège, P ;
Bergeron, J ;
Gaudet, D ;
Després, JP ;
Vohl, MC .
JOURNAL OF LIPID RESEARCH, 2005, 46 (02) :237-244
[2]   Adiponectin gene polymorphisms and adiponectin levels are indedendently associated with the development of hyperglycemia during a 3-year period -: The Epidemiologic Data on the Insulin Resistance Syndrome prospective study [J].
Fumeron, F ;
Aubert, R ;
Siddiq, A ;
Betoulle, D ;
Péan, F ;
Hadjadj, S ;
Tichet, J ;
Wilpart, E ;
Chesnier, MC ;
Balkau, B ;
Froguel, P ;
Marre, M .
DIABETES, 2004, 53 (04) :1150-1157
[3]  
*GENBANK, GENBANK IS NIH GEN S
[4]   An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance [J].
González-Sánchez, JL ;
Zabena, CA ;
Martínez-Larrad, MT ;
Fernández-Pérez, C ;
Pérez-Barba, M ;
Laakso, M ;
Serrano-Ríos, M .
OBESITY RESEARCH, 2005, 13 (05) :807-812
[5]  
GORSHUNSKA MY, 2007, ENDOKRINOLOGIYA, V12, P252
[6]   Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians [J].
Gu, HF ;
Abulaiti, A ;
Östenson, CG ;
Humphreys, K ;
Wahlestedt, C ;
Brookes, AJ ;
Efendic, S .
DIABETES, 2004, 53 :S31-S35
[7]   Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population [J].
Hara, K ;
Boutin, P ;
Mori, Y ;
Tobe, K ;
Dina, C ;
Yasuda, K ;
Yamauchi, T ;
Otabe, S ;
Okada, T ;
Eto, K ;
Kadowaki, H ;
Hagura, R ;
Akanuma, Y ;
Yazaki, Y ;
Nagai, R ;
Taniyama, M ;
Matsubara, K ;
Yoda, M ;
Nakano, Y ;
Kimura, S ;
Tomita, M ;
Kimura, S ;
Ito, C ;
Froguel, P ;
Kadowaki, T .
DIABETES, 2002, 51 (02) :536-540
[8]   Genetic variation at the adiponectin locus and risk of type 2 diabetes in women [J].
Hu, FB ;
Doria, A ;
Li, T ;
Meigs, JB ;
Liu, SM ;
Memisoglu, A ;
Hunter, D ;
Manson, JE .
DIABETES, 2004, 53 (01) :209-213
[9]   Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome [J].
Kissebah, AH ;
Sonnenberg, GE ;
Myklebust, J ;
Goldstein, M ;
Broman, K ;
James, RG ;
Marks, JA ;
Krakower, GR ;
Jacob, HJ ;
Weber, A ;
Martin, L ;
Blangero, J ;
Comuzzie, AG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) :14478-14483
[10]  
LIBANOV K, 2008, HUMAN DEV UKRAINE IN
123