GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains

被引：27

作者：

Justino de Araujo, Ana Carolina ^{[1
]}

Freitas, Priscilla Ramos ^{[1
]}

dos Santos Barbosa, Cristina Rodrigues ^{[1
]}

Muniz, Debora Feitosa ^{[1
]}

Rocha, Janaina Esmeraldo ^{[1
]}

Albuquerque da Silva, Ana Cristina ^{[1
]}

de Morals Oliveira-Tintino, Acera Datiane ^{[2
]}

Ribeiro-Filho, Jaime ^{[3
]}

da Silva, Luiz Everson ^{[4
]}

Confortin, Camila ^{[4
]}

do Amaral, Wanderlei ^{[5
]}

Deschamps, Cicero ^{[6
]}

Barbosa-Filho, Jose Maria ^{[7
]}

Ramos de Lima, Natanael Teles ^{[7
]}

Tintino, Saulo Relison ^{[1
]}

Melo Coutinho, Henrique Douglas ^{[1
]}

机构：

[1] Reg Univ Cariri, URCA, Dept Biol Chem, Crato, CE, Brazil

[2] Univ Fed Pernambuco, UFPE, Dept Antibiot, Recife, PE, Brazil

[3] IGM FIOCRUZ BA, Oswaldo Cruz Fdn, Goncalo Moniz Inst, Salvador, BA, Brazil

[4] Univ Fed Parana, UFPR, Post Grad Course Sustainable Territorial Dev, Matinhos, PR, Brazil

[5] Univ Fed Parana, UFPR, Dept Chem Technol, Curitiba, PR, Brazil

[6] Univ Fed Parana, UFPR, Post Grad Course Agron, Curitiba, PR, Brazil

[7] Univ Fed Paraiba, UFPB, Dept Pharm, Joao Pessoa, PB, Brazil

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 136卷

关键词：

Mikania cordifolia; Limonene; Bacterial resistance; Antibiotics; Modulation; CHEMICAL-COMPOSITION; GLOMERATA SPRENGEL; ANTIBIOTICS; RESISTANCE; INDUCTION; NETWORK; ACIDS;

D O I：

10.1016/j.fct.2019.111023

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The present study evaluated the effect of the essential oil of Mikania cordifolia (EOMc) and its major constituent limonene alone or associated with antibacterial drugs against Multidrug Resistant Bacteria (MDR). To evaluate the antibacterial activity, the minimum inhibitory concentrations (MIC) of the oil and limonene against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were determined. The antibiotic-modulating activity was assessed using subinhibitory concentrations (MIC/8) of these substances in combination with conventional antibacterial drugs. Although no relevant antibacterial activity of the natural products was detected, both substances modulated the action of antibiotics against resistant bacteria. The EOMc demonstrated the best modulating effect against P. aeruginosa, presenting synergistic effects when associated with gentamicin and norfloxacin. In addition, the oil reduced the MIC of norfloxacin against E. coli as well as reduced the MIC of gentamicin against S. aureus. On the other hand, the best effect of limonene was obtained against S. aureus. Thus, it is concluded that the essential oil Mikania cordifolia and the isolated compound limonene do not have clinically significant antibacterial effect, but modulate the action of antibiotics against MDR bacteria.

引用

页数：5

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