Why avoid the hippocampus? A comprehensive review

被引：313

作者：

Gondi, Vinai ^{[1
]}

Tome, Wolfgang A. ^{[1
,2
]}

Mehta, Minesh P. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Human Oncol, Ctr Comprehens Canc, Madison, WI 53792 USA

[2] Univ Wisconsin, Dept Med Phys, Ctr Comprehens Canc, Madison, WI 53792 USA

来源：

RADIOTHERAPY AND ONCOLOGY | 2010年 / 97卷 / 03期

关键词：

Hippocampal sparing; Brain metastases; Neurocognitive function; Whole-brain radiotherapy; RTOG; 0933; WHOLE-BRAIN RADIATION; QUALITY-OF-LIFE; DENTATE GYRUS; MOTEXAFIN GADOLINIUM; ADULT NEUROGENESIS; NEUROCOGNITIVE FUNCTION; RECOGNITION MEMORY; RANDOMIZED-TRIAL; GRANULE CELLS; PHASE-III;

D O I：

10.1016/j.radonc.2010.09.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this review article, we provide a detailed and comprehensive discussion of the rationale for using modern IMRT techniques to spare the subgranular zone of the hippocampus during cranial irradiation. We review the literature on neurocognitive effects of cranial irradiation; discuss clinical and preclinical data associating damage to neural progrenitor cells located in subgranular zone of the hippocampus with radiation-induced neurocognitive decline, specifically in terms of short-term memory formation and recall; and present a review of our pilot investigations into the feasibility and risks of sparing the subgranular zone of the hippocampus during whole-brain radiotherapy for brain metastases. We also introduce our phase II cooperative group clinical trial (RTOG 0933) designed to prospectively evaluate the postulated neurocognitive benefit of hippocampal subgranular zone sparing and scheduled to open in 2010. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 370-376

引用

页码：370 / 376

页数：7

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