Mitochondrial diseases and the role of the yeast models

被引：34

作者：

Rinaldi, Teresa ^{[2
]}

Dallabona, Cristina ^{[3
]}

Ferrero, Ileana ^{[3
]}

Frontali, Laura ^{[2
]}

Bolotin-Fukuhara, Monique ^{[1
]}

机构：

[1] Univ Paris 11, Inst Genet & Microbiol, CNRS, F-91405 Orsay, France

[2] Univ Roma La Sapienza, Dept Cell & Dev Biol, Inst Pasteur, Cenci Bolognetti Fdn, Rome, Italy

[3] Univ Parma, Dept Genet, I-43100 Parma, Italy

来源：

FEMS YEAST RESEARCH | 2010年 / 10卷 / 08期

关键词：

mitochondrial diseases; fusion; fission; mitochondrial transformation; mitochondrial tRNAs; mtDNA stability and maintenance; DYNAMIN-RELATED GTPASE; DNA-POLYMERASE-GAMMA; PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; DIFFERENTIATION-ASSOCIATED PROTEIN-1; ADENINE-NUCLEOTIDE TRANSLOCATOR; CYTOCHROME-B MUTATIONS; DOMINANT OPTIC ATROPHY; SACCHAROMYCES-CEREVISIAE; SUCCINATE-DEHYDROGENASE; MEMBRANE PROTEIN;

D O I：

10.1111/j.1567-1364.2010.00685.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nowadays, mitochondrial diseases are recognized and studied with much attention and they cannot be considered anymore as 'rare diseases'. Yeast has been an instrumental organism to understand the genetic and molecular aspects of the many roles of mitochondria within the cells. Thanks to the general conservation of mitochondrial genes and pathways between human and yeast, it can also be used to model some diseases. In this review, we focus on the most recent topics, exemplifying those for which yeast models have been especially valuable.

引用

页码：1006 / 1022

页数：17

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