A 15-year old girl with asthma and lower lobe bronchiectasis

被引:2
作者
Ricketti, Peter A. [1 ]
Unlde, David W. [2 ]
King, Katherine A. [3 ,4 ]
Cleri, Dennis J.
Ricketti, Anthony J. [5 ]
机构
[1] Rutgers State Univ, Sch Med, Dept Internal Med, Newark, NJ 07102 USA
[2] Catholic Univ Amer, Sch Nursing, Washington, DC 20064 USA
[3] Alfred I DuPont Hosp Children, Nemours, Dept Pediat, Div Pediat Pulmonol, Wilmington, DE USA
[4] Thomas Jefferson Univ, Philadelphia, PA 19107 USA
[5] Sch Grad Med Educ, S Orange, NJ USA
关键词
PRIMARY CILIARY DYSKINESIA; NASAL NITRIC-OXIDE; KARTAGENERS-SYNDROME; LUNG-FUNCTION; OTITIS-MEDIA; CHILDREN; DISEASE; POPULATION; EXPRESSION; DIAGNOSIS;
D O I
10.2500/aap.2015.36.3784
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Wet cough, wheeze, and sputum in an adolescent with evidence for bronchiectasis is an uncommon presentation. The differential diagnosis includes cystic fibrosis (CF), immunodeficiency disorders, complement deficiency, allergic bronchopulmonary aspergillosis, alpha-1 antitrypsin disease, repeated aspiration pneumonia, foreign body, bronchial carcinoid, unresolved right middle lobe pneumonia, and primary ciliary dyskinesia (PCD). The likely diagnosis proceeds from the more to less common in patients with these symptoms. The location of disease on computed tomography scanning, nasal and bronchial exhaled nitric oxide, identification of ultrastructural defects on electron microscopy, and specific genetic mutation help separate CF and PCD. Although differentiating these conditions is vital, the chronic management of the bronchiectasis usually includes clearance mechanisms, bronchodilators, regular exercise, appropriate vaccinations, and judicious antibiotics for airway infections.
引用
收藏
页码:82 / 86
页数:5
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