Vitamin D, Immunoregulation, and Rheumatoid Arthritis

被引：43

作者：

Wen, Hongyan ^{[1
,2
,3
]}

Baker, Joshua F. ^{[2
]}

机构：

[1] Shanxi Med Univ, Hosp 2, Taiyuan 030001, Shanxi Province, Peoples R China

[2] Univ Penn, Dept Med, Div Rheumatol, Philadelphia, PA 19104 USA

[3] VA Med Ctr, Philadelphia, PA USA

来源：

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY | 2011年 / 17卷 / 02期

关键词：

vitamin D; immunoregulation; rheumatoid arthritis; DENDRITIC CELL-DIFFERENTIATION; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; T-CELLS; 1,25-DIHYDROXYVITAMIN D-3; DISEASE-ACTIVITY; IMMUNOGLOBULIN PRODUCTION; D METABOLITES; TH17; CELLS; EXPRESSION; INHIBITION;

D O I：

10.1097/RHU.0b013e31820edd18

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In addition to being important in calcium and phosphorus metabolism, bone formation, and mineralization, vitamin D also plays a part in the maintenance of immune homeostasis. Vitamin D receptors are expressed in a number of different tissues, including, and perhaps most notably, on immune cells. The presence or absence of activated vitamin D has a number of effects on in vitro immune cell function. This review describes the possible immunoregulatory role of vitamin D in rheumatoid arthritis with clinical and animal studies.

引用

页码：102 / 107

页数：6

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