Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients

被引：19

作者：

Wang, Yang ^{[2
,4
]}

Wang, Lei ^{[3
]}

Li, Xingwang ^{[2
,3
,4
]}

Liu, Baocheng ^{[2
,4
]}

Zhao, Qingzhu ^{[2
,4
]}

Chen, Peng ^{[2
,4
]}

Wang, Ti ^{[2
,4
]}

Li, Tao ^{[2
,4
]}

Ji, Jue ^{[2
,4
]}

Yang, Fengping ^{[2
,4
]}

Wang, Quan ^{[1
]}

Wang, Jinfen ^{[6
]}

Xiao, Yanzeng ^{[6
]}

Xu, Yifeng ^{[5
]}

Feng, Guoyin ^{[5
]}

Peng, Zhihai ^{[1
]}

He, Lin ^{[2
,3
,4
]}

He, Guang ^{[2
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China

[2] Shanghai Jiao Tong Univ, Minist Educ, Bio X Ctr, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China

[3] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[4] Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[5] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

[6] Shanxi Canc Hosp, Taiyuan 320013, Peoples R China

来源：

BMC CANCER | 2010年 / 10卷

关键词：

DNA-REPAIR PROTEIN; LINKAGE DISEQUILIBRIUM; ASSOCIATION; LOCI; GENE; P53; SUSCEPTIBILITY; TESTS; MICE;

D O I：

10.1186/1471-2407-10-523

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance. Methods: To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering similar to 205.7 kb in the region of XRCC4. Results: We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005. Conclusions: Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.

引用

页数：6

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