Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine

被引：13

作者：

Kawase, Masaya ^{[1
,2
]}

Saito, Tadashi ^{[1
]}

Ogawa, Masafumi ^{[3
]}

Uejima, Hideki ^{[3
]}

Hatsuda, Yasutoshi ^{[3
]}

Kawanishi, Sonoyo ^{[3
]}

Hirotani, Yoshihiko ^{[3
]}

Myotoku, Michiaki ^{[3
]}

Ikeda, Kenji ^{[3
]}

Konishi, Hiroki ^{[3
]}

Iga, Ikumi ^{[3
]}

Yamakawa, Junji ^{[4
]}

Nishizawa, Seizi ^{[5
]}

Yamamoto, Kohji ^{[6
]}

Tani, Masahiko ^{[6
]}

机构：

[1] Osaka Univ, Radioisotope Res Ctr, Osaka 5600043, Japan

[2] Nagahama Inst Biosci & Technol, Shiga 5260829, Japan

[3] Osaka Ohtani Univ, Fac Pharmaceut Sci, Osaka 5848540, Japan

[4] Okayama Univ, Grad Sch Nat Sci & Technol, Kita Ku, Okayama 7008530, Japan

[5] Adv Infrared Spect, Tokyo 1930835, Japan

[6] Univ Fukui, Res Ctr Dev Far Infrared Reg, Fukui 9018507, Japan

来源：

ANALYTICAL SCIENCES | 2011年 / 27卷 / 02期

关键词：

TIME-DOMAIN SPECTROSCOPY; SPECTRA;

D O I：

10.2116/analsci.27.209

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD (R) (5 mg), Basen OD (R) (0.2 mg) and Gaster D (R) (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

引用

页码：209 / 212

页数：4

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